INT20495

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2001
Negated 3
Speculated 2
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 0.96
Pain Relevance 13.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
brain 8
hearts 4
caudate-putamen 3
ileum 2
neurosecretory cells 2
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 142 100.00 Very High Very High Very High
substance P 32 100.00 Very High Very High Very High
ischemia 20 100.00 Very High Very High Very High
Neuropeptide 14 100.00 Very High Very High Very High
Cholecystokinin 12 100.00 Very High Very High Very High
Catecholamine 3 100.00 Very High Very High Very High
antidepressant 2 99.16 Very High Very High Very High
antagonist 4 97.24 Very High Very High Very High
Dopamine 6 96.32 Very High Very High Very High
Nucleus accumbens 12 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 20 100.00 Very High Very High Very High
Urological Neuroanatomy 4 100.00 Very High Very High Very High
Stress 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of ischemia on cardiac Leucine enkephalin (Leu-enk) content, degradation and coronary release was studied in the isolated perfused hearts of male Sprague Dawley rats.
Regulation (effect) of Protein_catabolism (degradation) of enkephalin in hearts associated with ischemia and enkephalin
1) Confidence 0.62 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11471067 Disease Relevance 0.32 Pain Relevance 0.40
The influence of the catecholamine hormones and some of their metabolites on the enzymatic degradation of met-enkephalin by rat brain homogenates has been evaluated.
Regulation (influence) of Protein_catabolism (degradation) of met-enkephalin in brain associated with catecholamine and enkephalin
2) Confidence 0.62 Published 1982 Journal Endocrinology Section Abstract Doc Link 7053990 Disease Relevance 0 Pain Relevance 0.43
Boroleucine prolonged the leucine enkephalin degradation half-life 1.6-1.9-fold in each medium at 0.1 microM concentrations, 1/1000th the concentration of leucine enkephalin.
Regulation (prolonged) of Protein_catabolism (degradation) of enkephalin associated with enkephalin
3) Confidence 0.45 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 2143133 Disease Relevance 0 Pain Relevance 0.69
Boroleucine prolonged the leucine enkephalin degradation half-life 1.6-1.9-fold in each medium at 0.1 microM concentrations, 1/1000th the concentration of leucine enkephalin.
Regulation (prolonged) of Protein_catabolism (degradation) of enkephalin associated with enkephalin
4) Confidence 0.45 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 2143133 Disease Relevance 0 Pain Relevance 0.70
The effect of ischemia on cardiac Leucine enkephalin (Leu-enk) content, degradation and coronary release was studied in the isolated perfused hearts of male Sprague Dawley rats.
Regulation (effect) of Protein_catabolism (degradation) of enk in hearts associated with ischemia and enkephalin
5) Confidence 0.44 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11471067 Disease Relevance 0.32 Pain Relevance 0.40
The effect of postnatal administration of phenobarbital on enzymes degrading enkephalin was examined.
Regulation (effect) of Protein_catabolism (degrading) of enkephalin associated with enkephalin
6) Confidence 0.44 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 3885070 Disease Relevance 0 Pain Relevance 0.15
Considerable evidence has appeared recently connecting the mechanism of action of some antidepressant drugs with the inhibition of the enzymes responsible for enkephalin degradation.
Regulation (responsible) of Protein_catabolism (degradation) of enkephalin associated with antidepressant and enkephalin
7) Confidence 0.44 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9845280 Disease Relevance 0 Pain Relevance 0.40
This action mechanism could be mediated through the inhibition of the enzymes responsible for enkephalin degradation.
Regulation (responsible) of Protein_catabolism (degradation) of enkephalin associated with enkephalin
8) Confidence 0.42 Published 1997 Journal Life Sci. Section Abstract Doc Link 9395259 Disease Relevance 0 Pain Relevance 0.69
[Effect of central administration of leu-enkephalin on neurosecretory cells of the paraventricular nucleus of the hypothalamus and enterochromaffin cells of the stomach].
Regulation ([Effect) of Protein_catabolism (administration) of enkephalin in neurosecretory cells associated with enkephalin
9) Confidence 0.39 Published 1981 Journal Fiziol Zh SSSR Im I M Sechenova Section Title Doc Link 7286335 Disease Relevance 0 Pain Relevance 0.38
Inhibition of enkephalinase with thiorphan (0.3 microM) did not appear to affect Met-enkephalin metabolism.
Regulation (affect) of Protein_catabolism (metabolism) of Met-enkephalin associated with enkephalin
10) Confidence 0.36 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2983067 Disease Relevance 0 Pain Relevance 0.53
This investigation examined the importance of peptidases in the degradation of the neuropeptide enkephalin in the stomach wall of the rat.
Spec (examined) Regulation (importance) of Protein_catabolism (degradation) of enkephalin in stomach wall associated with neuropeptide and enkephalin
11) Confidence 0.27 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2405705 Disease Relevance 0 Pain Relevance 0.52
The effect on enkephalin degradation of the four highly potent organophosphorus anticholinesterases, soman, sarin, tabun and DFP was studied in synaptosomal fractions of rat brain striata.
Regulation (effect) of Protein_catabolism (degradation) of enkephalin in brain associated with enkephalin
12) Confidence 0.26 Published 1986 Journal Life Sci. Section Abstract Doc Link 3515093 Disease Relevance 0 Pain Relevance 0.45
The effects of various protease inhibitors on the stability of leucine enkephalin (Leu-Enk) and [D-Ala2,D-Leu5] enkephalin (DADLE) were investigated, and the permeability of these peptides was also examined in an in vitro Ussing chamber.
Spec (investigated) Regulation (effects) of Protein_catabolism (stability) of enkephalin associated with enkephalin
13) Confidence 0.25 Published 1998 Journal J Pharm Sci Section Abstract Doc Link 9548897 Disease Relevance 0 Pain Relevance 0.35
Neuropeptide metabolism on intact, regional brain slices: effect of dopaminergic agents on substance P, cholecystokinin and Met-enkephalin degradation.
Regulation (effect) of Protein_catabolism (degradation) of Met-enkephalin in brain associated with neuropeptide, enkephalin, cholecystokinin and substance p
14) Confidence 0.21 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7543572 Disease Relevance 0.06 Pain Relevance 0.97
Met-enkephalin degradation was decreased after haloperidol administration in both frontal cortex and caudate-putamen and unaffected by apomorphine administration.
Neg (unaffected) Regulation (unaffected) of Protein_catabolism (degradation) of Met-enkephalin in caudate-putamen associated with urological neuroanatomy and enkephalin
15) Confidence 0.15 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7543572 Disease Relevance 0.10 Pain Relevance 1.10
In the present study, the effect of neuroleptics and other dopaminergic compounds on substance P (SP), cholecystokinin and met-enkephalin degradation was determined on intact, regional, rat brain slices.
Regulation (effect) of Protein_catabolism (degradation) of met-enkephalin in brain associated with enkephalin, cholecystokinin and substance p
16) Confidence 0.15 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7543572 Disease Relevance 0.06 Pain Relevance 0.90
Enkephalin degradation in the guinea-pig ileum: effect of aminopeptidase inhibitors, puromycin and bestatin.
Regulation (effect) of Protein_catabolism (degradation) of Enkephalin in ileum associated with enkephalin
17) Confidence 0.15 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6822962 Disease Relevance 0 Pain Relevance 0.92
This enhancement cannot be explained by an effect on enkephalin degradation, but may be related to some other action of puromycin.
Regulation (effect) of Protein_catabolism (degradation) of enkephalin associated with enkephalin
18) Confidence 0.09 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6822962 Disease Relevance 0 Pain Relevance 1.03
In contrast, puromycin did not shift the concentration-response curve to Met-enkephalin in either the intact guinea-pig ileum or the ileal longitudinal muscle and, likewise, no alteration in the degradation of [3H]Leu- or Met-enkephalin occurred with puromycin.
Neg (no) Regulation (alteration) of Protein_catabolism (degradation) of enkephalin in longitudinal muscle associated with enkephalin
19) Confidence 0.08 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6822962 Disease Relevance 0 Pain Relevance 1.17
Met-enkephalin degradation was decreased after haloperidol administration in both frontal cortex and caudate-putamen and unaffected by apomorphine administration.
Neg (unaffected) Regulation (unaffected) of in frontal cortex Protein_catabolism (degradation) of Met-enkephalin in caudate-putamen associated with urological neuroanatomy and enkephalin
20) Confidence 0.05 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7543572 Disease Relevance 0.10 Pain Relevance 1.10

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