INT20496

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1983
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.86
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
Caco-2 2
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 50 100.00 Very High Very High Very High
Analgesic 6 100.00 Very High Very High Very High
ischemia 10 99.68 Very High Very High Very High
Dynorphin 1 84.56 Quite High
tail-flick 1 77.76 Quite High
narcan 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 10 99.68 Very High Very High Very High
Stress 1 66.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, enzymes involved in enkephalin degradation were decreased during perfusion (39%) and increased during ischemia (50%).
Positive_regulation (increased) of Protein_catabolism (degradation) of enkephalin associated with ischemia and enkephalin
1) Confidence 0.50 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11471067 Disease Relevance 0.86 Pain Relevance 0.89
The data suggest that inhibition of the metalloendopeptidase decreases the rate of degradation of endogenous enkephalins, however the analgesic properties of the inhibitors do not seem to be related to their inhibitory potencies.
Positive_regulation (related) of Protein_catabolism (degradation) of enkephalin associated with analgesic and enkephalin
2) Confidence 0.49 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6383843 Disease Relevance 0 Pain Relevance 0.99
Its properties, such as its subcellular localization, substrate specificity, pH optimum, and molecular weight, distinguish it from leucine aminopeptidase, aminopeptidase A, aminopeptidase B, aminopeptidase M, and the soluble aminopeptidase for enkephalin degradation.
Positive_regulation (soluble) of Protein_catabolism (degradation) of enkephalin associated with enkephalin
3) Confidence 0.49 Published 1983 Journal Biochemistry Section Abstract Doc Link 6838839 Disease Relevance 0 Pain Relevance 0.43
Boroleucine prolonged the leucine enkephalin degradation half-life 1.6-1.9-fold in each medium at 0.1 microM concentrations, 1/1000th the concentration of leucine enkephalin.
Positive_regulation (prolonged) of Protein_catabolism (degradation) of enkephalin associated with enkephalin
4) Confidence 0.46 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 2143133 Disease Relevance 0 Pain Relevance 0.69
This finding indicates that the very rapid degradation of Leu-Enk on the apical side of Caco-2 monolayers was due to aminopeptidases.
Positive_regulation (due) of Protein_catabolism (degradation) of Enk in Caco-2
5) Confidence 0.45 Published 1999 Journal Life Sci. Section Abstract Doc Link 10210267 Disease Relevance 0 Pain Relevance 0.17
These data support the importance of aminopeptidase activity to the degradation of enkephalin and indicate that enzymes which have properties in common with Leu-aminopeptidases rather than arylamidases may be the primary aminopeptidases responsible for terminating the pharmacological actions of enkephalins in intact guinea-pig ileal preparations.
Positive_regulation (importance) of Protein_catabolism (degradation) of enkephalin associated with enkephalin
6) Confidence 0.16 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6822962 Disease Relevance 0 Pain Relevance 1.02
Mn2+ activates SI on Met-enkephalin degradation, but inhibits SII, MI, and MII.
Positive_regulation (activates) of Protein_catabolism (degradation) of Met-enkephalin associated with enkephalin
7) Confidence 0.12 Published 1988 Journal J. Neurosci. Res. Section Abstract Doc Link 3172279 Disease Relevance 0 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox