INT204967

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.41
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Eri1) RNA binding (Eri1) rRNA binding (Eri1)
nucleus (Eri1) intracellular (Eri1) cytoplasm (Eri1)
Anatomy Link Frequency
dopaminergic neurons 1
Eri1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 1 81.04 Quite High
Paracetamol 4 76.32 Quite High
Dopamine 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 53 99.96 Very High Very High Very High
Toxicity 17 99.00 Very High Very High Very High
Stress 23 92.60 High High
Parkinson's Disease 5 80.76 Quite High
Contagious Ecthyma 3 80.72 Quite High
Death 10 50.00 Quite Low
Injury 5 48.16 Quite Low
Reprotox - General 3 1 25.96 Quite Low
Disease 7 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Silencing of the PINK1 gene expression did not cause a loss of the dopaminergic neurons in the PINK1 RNAi transgenic mice.

2.

Negative_regulation (loss) of RNAi in dopaminergic neurons associated with targeted disruption
1) Confidence 0.17 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.93 Pain Relevance 0
While RNAi depletion of Keap1 led to reduced toxicity following exposure to DNCB, depletion of Nrf2 and NF-?
Negative_regulation (depletion) of RNAi associated with toxicity
2) Confidence 0.01 Published 2010 Journal Biochemical Pharmacology Section Abstract Doc Link PMC2884179 Disease Relevance 0.48 Pain Relevance 0.12

General Comments

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