INT204970

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Park7) mitochondrion organization (Park7) response to stress (Park7)
cytoplasm (Park7) cell proliferation (Park7) cytosol (Park7)
Anatomy Link Frequency
nucleus 1
dopaminergic neuron 1
Park7 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 29 5.00 Very Low Very Low Very Low
Dopamine 17 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Ventral tegmentum 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
monoamine 6 5.00 Very Low Very Low Very Low
Substantia nigra 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Locus ceruleus 4 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 56 99.40 Very High Very High Very High
Disease 183 98.92 Very High Very High Very High
Stress 28 97.96 Very High Very High Very High
Death 26 97.28 Very High Very High Very High
Parkinson's Disease 96 89.56 High High
Apoptosis 9 80.36 Quite High
Congenital Anomalies 3 68.40 Quite High
Embryonic Lethality 1 67.04 Quite High
Toxicity 12 53.92 Quite High
Pressure And Volume Under Development 1 28.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also DJ-1 and LRRK2 proteins were shown to be localized into the mitochondria (Canet-Aviles et al., 2004; West et al., 2005).
Localization (localized) of DJ-1
1) Confidence 0.54 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.47 Pain Relevance 0
Deletion of either the Parkin or DJ-1 genes by gene knockout approach does not cause dopaminergic neuron death 43-49.
Localization (Deletion) of DJ-1 in dopaminergic neuron associated with targeted disruption and death
2) Confidence 0.42 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 1.54 Pain Relevance 0
Under normal conditions, DJ-1 preferentially localizes in the cytosol, but under conditions of oxidative stress it translocates to the mitochondria and nucleus (Zhang et al., 2005).
Localization (localizes) of DJ-1 in nucleus associated with stress
3) Confidence 0.39 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.75 Pain Relevance 0

General Comments

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