INT20498

Context Info Confidence 0.59 First Reported 1987 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 4.50 Pain Relevance 2.43

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)

Anatomy Link Frequency plasma 2 blood 2 body 2 Nppa (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 7 99.96 tetrodotoxin 4 99.70 opiate 2 99.28 Morphine 12 99.26 antagonist 4 99.20 Neurotransmitter 1 98.78 Neuropeptide 1 98.34 opioid receptor 3 95.92 sodium channel 2 88.68 Pain 1 85.92

Disease Link Frequency Relevance Heat Natriuresis 16 100.00 Body Weight 8 100.00 Pressure Volume 2 Under Development 1 100.00 Congenital Anomalies 4 99.36 Appetite Loss 4 98.92 Sprains And Strains 1 98.60 Obesity 11 98.36 Dyspnea 11 96.92 Hypertrophy 1 93.24 Myocardial Infarction 1 92.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The quaternary antagonist N-methylnaltrexone (1 mg/kg) failed to block the fentanyl-induced increase of ANF, suggesting that opiates bring about their action on ANF via a central mechanism.

Negative_regulation (block) of Positive_regulation (increase) of ANF associated with antagonist and opiate

1) Confidence 0.59 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2961585 Disease Relevance 0.15 Pain Relevance 0.54

Abolishing contraction with 10 microM tetrodotoxin significantly reduced ANP accumulated in 2 h.

Negative_regulation (reduced) of Positive_regulation (accumulated) of ANP associated with tetrodotoxin

2) Confidence 0.43 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.16 Pain Relevance 0.19

Propranolol and tetrodotoxin significantly (p<0.01) inhibited 55% and 60%, respectively, the toxin-induced ANP release.

Negative_regulation (inhibited) of Positive_regulation (toxin-induced) of ANP associated with tetrodotoxin

3) Confidence 0.43 Published 2008 Journal Peptides Section Abstract Doc Link 18191303 Disease Relevance 0.13 Pain Relevance 0.27

Perfusion with 10(-5) M brimonidine (full alpha2-adrenoceptor agonist) inhibited moxonidine-stimulated ANP release.

Negative_regulation (inhibited) of Positive_regulation (moxonidine-stimulated) of ANP associated with agonist

4) Confidence 0.43 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16774751 Disease Relevance 0.22 Pain Relevance 0.28

Morphine induced a transient, dose-dependent reduction in blood pressure (from 114+/-1 to 71+/-6 mm Hg at 10.0 mg/kg body weight) and a dose-dependent elevation of plasma ANF.

Negative_regulation (reduction) of Positive_regulation (elevation) of ANF in body associated with body weight and morphine

5) Confidence 0.42 Published 1997 Journal Kidney Blood Press. Res. Section Abstract Doc Link 9192906 Disease Relevance 0.44 Pain Relevance 0.59

Our results suggest that the disturbed control of neuropeptides and neurotransmitters as well as changes in peripheral metabolism may explain the impaired responsibility of ANP to hemodynamic stimuli in anorectic and obese patients.

Negative_regulation (impaired) of Positive_regulation (responsibility) of ANP associated with appetite loss, neurotransmitter, obesity and neuropeptide

6) Confidence 0.42 Published 1995 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7858731 Disease Relevance 1.50 Pain Relevance 0.24

Furthermore, injection of 10 micrograms/kg of fentanyl decreased blood pressure and increased plasma IR-ANP and right atrial pressure in both strains.

Negative_regulation (decreased) of Positive_regulation (increased) of IR-ANP in blood associated with pressure volume 2 under development and sprains and strains

7) Confidence 0.37 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2143537 Disease Relevance 0.27 Pain Relevance 0.12

A decrease of fractional shortening and increased levels of IrANP are late phenomena.

Negative_regulation (decrease) of Positive_regulation (increased) of IrANP

8) Confidence 0.09 Published 1987 Journal Acta Med. Scand. Suppl. Section Abstract Doc Link 2962421 Disease Relevance 1.14 Pain Relevance 0.07

Spironolactone induced a significant reduction of plasma volume (42.1 +/- 5.5 to 36.1 +/- 6.6 mL/kg body weight, P < .01) and of the concentration of alpha-atrial natriuretic peptide (alpha-ANP) (39.8 +/- 22 to 27.7 +/- 20 pg/mL, P < .01); in addition, a pronounced increase in plasma renin activity (PRA) (1.1 +/- 0.9 to 7.5 +/- 3.4 ng/mL/h, P < .001) was induced by the treatment.

Negative_regulation (reduction) of Positive_regulation (induced) of alpha-ANP in plasma associated with natriuresis and body weight

9) Confidence 0.03 Published 1996 Journal Hepatology Section Abstract Doc Link 8621132 Disease Relevance 0.49 Pain Relevance 0.12

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