INT20498

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.50
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
plasma 2
blood 2
body 2
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 99.96 Very High Very High Very High
tetrodotoxin 4 99.70 Very High Very High Very High
opiate 2 99.28 Very High Very High Very High
Morphine 12 99.26 Very High Very High Very High
antagonist 4 99.20 Very High Very High Very High
Neurotransmitter 1 98.78 Very High Very High Very High
Neuropeptide 1 98.34 Very High Very High Very High
opioid receptor 3 95.92 Very High Very High Very High
sodium channel 2 88.68 High High
Pain 1 85.92 High High
Disease Link Frequency Relevance Heat
Natriuresis 16 100.00 Very High Very High Very High
Body Weight 8 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 1 100.00 Very High Very High Very High
Congenital Anomalies 4 99.36 Very High Very High Very High
Appetite Loss 4 98.92 Very High Very High Very High
Sprains And Strains 1 98.60 Very High Very High Very High
Obesity 11 98.36 Very High Very High Very High
Dyspnea 11 96.92 Very High Very High Very High
Hypertrophy 1 93.24 High High
Myocardial Infarction 1 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The quaternary antagonist N-methylnaltrexone (1 mg/kg) failed to block the fentanyl-induced increase of ANF, suggesting that opiates bring about their action on ANF via a central mechanism.
Negative_regulation (block) of Positive_regulation (increase) of ANF associated with antagonist and opiate
1) Confidence 0.59 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2961585 Disease Relevance 0.15 Pain Relevance 0.54
Abolishing contraction with 10 microM tetrodotoxin significantly reduced ANP accumulated in 2 h.
Negative_regulation (reduced) of Positive_regulation (accumulated) of ANP associated with tetrodotoxin
2) Confidence 0.43 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.16 Pain Relevance 0.19
Propranolol and tetrodotoxin significantly (p<0.01) inhibited 55% and 60%, respectively, the toxin-induced ANP release.
Negative_regulation (inhibited) of Positive_regulation (toxin-induced) of ANP associated with tetrodotoxin
3) Confidence 0.43 Published 2008 Journal Peptides Section Abstract Doc Link 18191303 Disease Relevance 0.13 Pain Relevance 0.27
Perfusion with 10(-5) M brimonidine (full alpha2-adrenoceptor agonist) inhibited moxonidine-stimulated ANP release.
Negative_regulation (inhibited) of Positive_regulation (moxonidine-stimulated) of ANP associated with agonist
4) Confidence 0.43 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16774751 Disease Relevance 0.22 Pain Relevance 0.28
Morphine induced a transient, dose-dependent reduction in blood pressure (from 114+/-1 to 71+/-6 mm Hg at 10.0 mg/kg body weight) and a dose-dependent elevation of plasma ANF.
Negative_regulation (reduction) of Positive_regulation (elevation) of ANF in body associated with body weight and morphine
5) Confidence 0.42 Published 1997 Journal Kidney Blood Press. Res. Section Abstract Doc Link 9192906 Disease Relevance 0.44 Pain Relevance 0.59
Our results suggest that the disturbed control of neuropeptides and neurotransmitters as well as changes in peripheral metabolism may explain the impaired responsibility of ANP to hemodynamic stimuli in anorectic and obese patients.
Negative_regulation (impaired) of Positive_regulation (responsibility) of ANP associated with appetite loss, neurotransmitter, obesity and neuropeptide
6) Confidence 0.42 Published 1995 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7858731 Disease Relevance 1.50 Pain Relevance 0.24
Furthermore, injection of 10 micrograms/kg of fentanyl decreased blood pressure and increased plasma IR-ANP and right atrial pressure in both strains.
Negative_regulation (decreased) of Positive_regulation (increased) of IR-ANP in blood associated with pressure volume 2 under development and sprains and strains
7) Confidence 0.37 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2143537 Disease Relevance 0.27 Pain Relevance 0.12
A decrease of fractional shortening and increased levels of IrANP are late phenomena.
Negative_regulation (decrease) of Positive_regulation (increased) of IrANP
8) Confidence 0.09 Published 1987 Journal Acta Med. Scand. Suppl. Section Abstract Doc Link 2962421 Disease Relevance 1.14 Pain Relevance 0.07
Spironolactone induced a significant reduction of plasma volume (42.1 +/- 5.5 to 36.1 +/- 6.6 mL/kg body weight, P < .01) and of the concentration of alpha-atrial natriuretic peptide (alpha-ANP) (39.8 +/- 22 to 27.7 +/- 20 pg/mL, P < .01); in addition, a pronounced increase in plasma renin activity (PRA) (1.1 +/- 0.9 to 7.5 +/- 3.4 ng/mL/h, P < .001) was induced by the treatment.
Negative_regulation (reduction) of Positive_regulation (induced) of alpha-ANP in plasma associated with natriuresis and body weight
9) Confidence 0.03 Published 1996 Journal Hepatology Section Abstract Doc Link 8621132 Disease Relevance 0.49 Pain Relevance 0.12

General Comments

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