INT204995

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

response to stress (Ppp1r15b, Pink1) cytosol (Pink1) mitochondrion (Pink1)
kinase activity (Pink1) cytoplasm (Pink1)
Anatomy Link Frequency
nerve 2
Ppp1r15b (Mus musculus)
Pink1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
dopaminergic neurodegeneration 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 48 99.78 Very High Very High Very High
Parkinson's Disease 5 93.00 High High
Contagious Ecthyma 3 57.60 Quite High
Death 7 50.00 Quite Low
Reprotox - General 3 1 38.20 Quite Low
Disease 7 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low
Embryonic Lethality 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Stroke 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these transgenic mice, the expression of the PINK1 shRNA was tightly regulated by the Cre-loxP system and activation of the RNAi transgene resulted in silenced expression of the Pink1 gene in various tissues and to less than 5% of the normal levels in the central nerve system.
Cre-loxP Regulation (regulated) of Gene_expression (expression) of PINK1 shRNA in nerve associated with targeted disruption
1) Confidence 0.01 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.97 Pain Relevance 0

General Comments

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