INT204996

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Park7, Pink1) response to stress (Park7, Pink1) cytoplasm (Park7, Pink1)
cytosol (Park7, Pink1) mitochondrion organization (Park7) cell proliferation (Park7)
Anatomy Link Frequency
dopaminergic neurons 1
Park7 (Mus musculus)
Pink1 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 1 87.32 High High
Central nervous system 4 81.24 Quite High
Dopamine 16 53.92 Quite High
midbrain 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 99.92 Very High Very High Very High
Disease 95 99.88 Very High Very High Very High
Death 21 87.96 High High
Targeted Disruption 54 69.36 Quite High
Neurodegenerative Disease 4 66.72 Quite High
Cytomegalovirus Infection 3 62.04 Quite High
Toxicity 7 60.48 Quite High
Parkinson's Disease 54 27.48 Quite Low
Stress 17 17.40 Low Low
Aging 2 13.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PINK1 and parkin also form a functional E3 ligase complex with DJ-1, which promotes degradation of misfolded parkin substrates by UPS, including parkin itself and synphilin-1.
DJ-1 Binding (complex) of PINK1
1) Confidence 0.34 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.62 Pain Relevance 0
PINK1 is associated with familial Parkinson's disease that is characterized by progressive degeneration of the dopaminergic neurons in SNc and the dopaminergic terminals in the striatum.
Parkinson Binding (associated) of PINK1 in dopaminergic neurons associated with disease
2) Confidence 0.27 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.47 Pain Relevance 0.11

General Comments

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