INT205

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Context Info
Confidence 0.58
First Reported 1977
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.23
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cbr1) oxidoreductase activity (Cbr1) plasma membrane (Cbr1)
nucleus (Cbr1) cytoplasm (Cbr1)
Anatomy Link Frequency
uterus 1
superior 1
lung 1
Cbr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 13 99.72 Very High Very High Very High
cINOD 9 99.68 Very High Very High Very High
Pain 2 99.56 Very High Very High Very High
Arthritis 7 99.32 Very High Very High Very High
Analgesic 10 99.28 Very High Very High Very High
Morphine 12 98.10 Very High Very High Very High
Paracetamol 4 97.74 Very High Very High Very High
opiate 1 96.76 Very High Very High Very High
aspirin 5 92.00 High High
Potency 2 91.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 22 99.72 Very High Very High Very High
Pain 2 99.56 Very High Very High Very High
Arthritis 4 99.32 Very High Very High Very High
Granuloma 3 98.20 Very High Very High Very High
Fever 3 98.04 Very High Very High Very High
Pressure And Volume Under Development 4 97.48 Very High Very High Very High
Erythema 2 96.36 Very High Very High Very High
Toxicity 5 94.32 High High
Experimental Arthritis 3 93.84 High High
Pleurisy 2 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The compounds did not differ in their in vitro enzyme inhibition effects, both failing to inhibit 5- and 15-lipoxygenase and both inhibiting prostaglandin synthetase.
Negative_regulation (inhibit) of prostaglandin synthetase
1) Confidence 0.58 Published 1993 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8424114 Disease Relevance 0.41 Pain Relevance 0.25
The activity of LM 22070 is either the same as (antipyretic action) or inferior to (analgesic and anti-inflammatory activity and inhibition of prostaglandin-synthetase) that of indomethacin, but always markedly superior to that of phenylbutazone.
Negative_regulation (inhibition) of prostaglandin-synthetase in superior associated with inflammation and analgesic
2) Confidence 0.57 Published 1979 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 112931 Disease Relevance 0.82 Pain Relevance 0.56
In vitro, its inhibition of prostaglandin-synthetase in guinea-pig lung was appreciably more powerful than that of indomethacin.
Negative_regulation (inhibition) of prostaglandin-synthetase in lung
3) Confidence 0.57 Published 1979 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 112931 Disease Relevance 0.88 Pain Relevance 0.58
The potentiation of some spasmogens by indomethacin, an inhibitor of prostaglandin synthetase activity, in the isolated rat uterus is reported.
Negative_regulation (inhibitor) of prostaglandin synthetase in uterus
4) Confidence 0.43 Published 1977 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17703 Disease Relevance 0.07 Pain Relevance 0.16
Phenylbutazone, aminopyrine, 1,3-diphenylisobenzofuran, paracetamol, p-aminophenol, p-phenetidine and other o- and m-substituted aminophenol derivatives were cooxygenated, whereby prostaglandin synthetase inhibition was significantly weakened due to the formation of less inhibitory metabolites.
Negative_regulation (inhibition) of prostaglandin synthetase associated with paracetamol
5) Confidence 0.25 Published 1983 Journal Pharmacology Section Abstract Doc Link 6419240 Disease Relevance 0 Pain Relevance 0.34
Unlike other NSAIDs, it was a weak inhibitor of prostaglandin synthetase.
Negative_regulation (inhibitor) of prostaglandin synthetase associated with cinod
6) Confidence 0.21 Published 1980 Journal J Rheumatol Suppl Section Abstract Doc Link 6771399 Disease Relevance 0.45 Pain Relevance 0.27
The data suggested that there may be mechanisms of antiinflammatory activity which do not relate to inhibition of prostaglandin synthetase.
Negative_regulation (inhibition) of prostaglandin synthetase associated with inflammation
7) Confidence 0.21 Published 1980 Journal J Rheumatol Suppl Section Abstract Doc Link 6771399 Disease Relevance 0.43 Pain Relevance 0.26
The weak prostaglandin synthetase inhibiting properties of this compound differentiate it from other acid anti-inflammatory compounds.
Negative_regulation (inhibiting) of prostaglandin synthetase associated with inflammation
8) Confidence 0.10 Published 1977 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18568 Disease Relevance 0.98 Pain Relevance 0.65
Since morphine releases histamine and alpha-FMH inhibits histamine synthesis, our data demonstrating that an inhibitor of prostaglandin-synthetase showed efficacy only in animals responding with fever to the higher dose of the opiate, suggests a physiological antagonism between histamine and prostaglandins on mechanisms underlying hyper/hypothermic responses to morphine.
Negative_regulation (inhibitor) of prostaglandin-synthetase associated with opiate, fever and morphine
9) Confidence 0.09 Published 1990 Journal Agents Actions Section Abstract Doc Link 2371924 Disease Relevance 0.18 Pain Relevance 1.21
The purpose of this investigation was to determine the long-term effect of enterically administered indomethacin (a prostaglandin synthetase inhibitor) on reproduction in Peromyscus maniculatus (deermice) under both laboratory and field conditions.
Negative_regulation (inhibitor) of prostaglandin synthetase
10) Confidence 0.05 Published 1983 Journal Biol. Reprod. Section Abstract Doc Link 6403066 Disease Relevance 0 Pain Relevance 0

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