INT205021

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.15
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) intracellular (Egfr)
enzyme binding (Egfr) cytoplasm (Egfr) signal transducer activity (Egfr)
Anatomy Link Frequency
renal tubule 2
tongue 2
lung 2
Egfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 35 52.24 Quite High
depression 4 50.56 Quite High
Inflammation 28 5.00 Very Low Very Low Very Low
Antihistamine 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
pruritus 8 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
ischemia 7 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 4 99.92 Very High Very High Very High
Solid Tumor 8 99.32 Very High Very High Very High
Apoptosis 8 99.20 Very High Very High Very High
Colon Cancer 36 98.36 Very High Very High Very High
Squamous Cell Neoplasms 4 97.80 Very High Very High Very High
Hypomagnesemia 100 97.40 Very High Very High Very High
Disease 5 95.52 Very High Very High Very High
Malignant Neoplastic Disease 6 90.64 High High
Adhesions 4 89.52 High High
Injury 43 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased EGFR expression in the ascending loop of Henle, where 70% of filtered magnesium is reabsorbed, may result in damage to the renal tubule and interfere with magnesium transport85,88.
Positive_regulation (Increased) of Gene_expression (expression) of EGFR in renal tubule
1) Confidence 0.64 Published 2010 Journal Current Oncology Section Body Doc Link PMC2901793 Disease Relevance 1.15 Pain Relevance 0.03
EGFR is overexpressed in a variety of solid tumors, including colorectal cancer (CRC), squamous cell cancer of the head and neck, and non-small-cell lung cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGFR in lung associated with lung cancer, squamous cell neoplasms, colon cancer and solid tumor
2) Confidence 0.64 Published 2010 Journal Current Oncology Section Body Doc Link PMC2901793 Disease Relevance 0.91 Pain Relevance 0
EGFR overexpression is associated with poorer prognosis in these malignancies10–14 and, in CRC, may be associated with an advanced disease stage15–18.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFR associated with colon cancer and disease
3) Confidence 0.64 Published 2010 Journal Current Oncology Section Body Doc Link PMC2901793 Disease Relevance 0.94 Pain Relevance 0
EGFR is overexpressed in a variety of solid tumors, including colorectal cancer (CRC), and its overexpression is associated with poorer prognosis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of EGFR associated with colon cancer and solid tumor
4) Confidence 0.43 Published 2010 Journal Current Oncology Section Abstract Doc Link PMC2901793 Disease Relevance 0.56 Pain Relevance 0
Expression of the cell cycle inhibitor p16 decreased, whereas epidermal growth factor receptor expression increased in the tongue.
Positive_regulation (increased) of Gene_expression (expression) of epidermal growth factor receptor in tongue
5) Confidence 0.21 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.46 Pain Relevance 0
While there was no change in the expression of LIFR, the expression of gp130 and EGFR were elevated by 1.5- and 1.44-fold, respectively.
Positive_regulation (elevated) of Gene_expression (expression) of EGFR
6) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.14 Pain Relevance 0.03

General Comments

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