INT205030

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

response to stress (Crh, Crhr1) signal transduction (Crhr1) extracellular space (Crh)
extracellular region (Crh) plasma membrane (Crhr1) signal transducer activity (Crhr1)
Crh (Mus musculus)
Crhr1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 1 94.48 High High
alcohol 11 93.60 High High
withdrawal 2 92.96 High High
amygdala 51 86.68 High High
gABA 25 74.48 Quite High
Neuropeptide 2 59.04 Quite High
GABAergic 16 50.00 Quite Low
addiction 8 7.32 Low Low
antagonist 9 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 28 97.84 Very High Very High Very High
Stress 6 97.12 Very High Very High Very High
Alcohol Addiction 8 93.60 High High
Aggression 55 92.40 High High
Targeted Disruption 15 82.40 Quite High
Recurrence 1 82.00 Quite High
Lung Cancer 4 34.96 Quite Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRF acts primarily on CRFR1 [11-13], but can also activate CRF receptor 2 (CRFR2) with less efficacy [14,15].
CRF Positive_regulation (activate) of CRF receptor
1) Confidence 0.54 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.91 Pain Relevance 0.03
A switch in coupling from AC9 to AC7 results in increased cAMP signaling when CRF1 is activated by CRF.
CRF Positive_regulation (activated) of CRF1
2) Confidence 0.16 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.42 Pain Relevance 0.48

General Comments

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