INT205043

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (SCARA3) endoplasmic reticulum (SCARA3)
SCARA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 3 10.28 Low Low
Dopamine 3 9.84 Low Low
substance P 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Enkephalin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 90 100.00 Very High Very High Very High
Hypoxia 51 99.06 Very High Very High Very High
Breast Cancer 33 95.60 Very High Very High Very High
Cancer 21 94.08 High High
Disease 81 88.80 High High
Hepatocellular Cancer 3 81.76 Quite High
Apoptosis 90 79.36 Quite High
Cognitive Disorder 6 74.08 Quite High
Alzheimer's Dementia 114 68.96 Quite High
Toxicity 3 65.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing caesarean sections rates (CSR) are a major public health concern and the prevention of the first caesarean section, which often leads to repeat operations, is an important issue.
Positive_regulation (Increasing) of CSR
1) Confidence 0.30 Published 2007 Journal BMC Pregnancy Childbirth Section Abstract Doc Link PMC1821336 Disease Relevance 0.05 Pain Relevance 0
This result underlines the importance of the T40 CSR, which is included within the T40/IDE products and AChE586-599, and provides an insight into the identity of an AChE domain that may cooperate with A?
Positive_regulation (included) of CSR
2) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.48 Pain Relevance 0
IDE catalysis generated CSR species that are highly dependent on pH for their surface-tension activity, which appeared to be solely the consequence of the presence of some CSR species and could not be explained by only the presence of hydrophobic or aromatic residues within the peptide sequences.
Positive_regulation (generated) of CSR
3) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.20 Pain Relevance 0
These temporal secondary structure changes correlated with the progressive accumulation of CSR species or their precursors peaking at 30 min (Figure 2E).
Positive_regulation (accumulation) of CSR
4) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.05 Pain Relevance 0
However, the mechanism of induced stress response by I3C is still unknown.
Positive_regulation (induced) of stress response associated with stress
5) Confidence 0.11 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 1.22 Pain Relevance 0
The upregulation of CYP1A1 and CYP1B1 may be linked to activation of genes involved with hypoxic stress response, although the consequences of upregulated stress response appear somewhat contradictory.
Positive_regulation (upregulated) of stress response associated with stress and hypoxia
6) Confidence 0.07 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.64 Pain Relevance 0
Transcript of heme oxygenase 1 (HMOX1), an essential enzyme in heme catabolism and a direct target of HIF1 (see stress response), was also upregulated.
Positive_regulation (upregulated) of stress response associated with stress
7) Confidence 0.07 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.30 Pain Relevance 0

General Comments

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