INT205087

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.86
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ISL1) cytoplasm (ISL1)
Anatomy Link Frequency
liver 2
ganglion 2
ISL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 3 78.16 Quite High
Enkephalin 3 75.40 Quite High
Dopamine 2 74.52 Quite High
Neurotransmitter 4 73.84 Quite High
Glutamate receptor 1 34.96 Quite Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Islet Cell Adenoma 58 100.00 Very High Very High Very High
Ganglion Cysts 24 100.00 Very High Very High Very High
Insulinoma 4 99.12 Very High Very High Very High
Cancer 82 97.04 Very High Very High Very High
Hyperglycemia 6 96.00 Very High Very High Very High
Diabetes Mellitus 38 94.64 High High
Pancreatic Cancer 54 92.88 High High
Syndrome 6 91.80 High High
Multiple Endocrine Neoplasia Type 1 4 91.44 High High
Adenocarcinoma 134 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cells expressed transcription factors pdx-1, pax-6, and isl-1, all three are central controlling genes capable of reprogramming nonpancreatic cells to surrogate ?
Positive_regulation (factors) of Gene_expression (expressed) of isl-1
1) Confidence 0.26 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.25 Pain Relevance 0
Accordingly, this microenvironment may promote the expression of genes common to both ganglion and type-II cells (including Pax6, Islet1 and neurofilament).
Spec (may) Positive_regulation (promote) of Gene_expression (expression) of Islet1 in ganglion associated with ganglion cysts
2) Confidence 0.08 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.54 Pain Relevance 0.15
Our analysis identified additional genes, including AXL, MFAB, and AXIN2, whose elevated expression in islet cell tumors suggests signal transduction pathways important in their development.
Positive_regulation (elevated) of Gene_expression (expression) of islet associated with islet cell adenoma
3) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.58 Pain Relevance 0
Consistent with previously published findings, genes with significantly elevated expression in islet cell tumors included insulinoma-associated 1 (INSM1), glutaminyl-peptide cyclotransferase (QPCT), fibrinogen B beta polypeptide (FGB), peroxisomal biogenesis factor 7 (PEX7).
Positive_regulation (elevated) of Gene_expression (expression) of islet associated with islet cell adenoma and insulinoma
4) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.04 Pain Relevance 0.04
Delivery of the Pdx-1 gene or NeuroD and BTC genes to the liver resulted in the expression of insulin and other islet-specific genes in liver.
Positive_regulation (resulted) of Gene_expression (expression) of islet in liver
5) Confidence 0.01 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.43 Pain Relevance 0

General Comments

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