INT205095

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.58
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CELA3A)
Anatomy Link Frequency
acinar cells 2
CELA3A (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 66.64 Quite High
Somatostatin 2 30.68 Quite Low
Chronic pancreatitis 2 25.88 Quite Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 134 98.64 Very High Very High Very High
Islet Cell Adenoma 58 91.96 High High
Cancer 82 89.44 High High
Pancreatic Cancer 54 83.36 Quite High
Lymphatic System Cancer 10 81.20 Quite High
Liposarcoma 2 78.40 Quite High
Thyroid Neoplasm 2 77.88 Quite High
Skin Cancer 2 75.84 Quite High
Leukemia 4 75.44 Quite High
Fibrosarcoma 2 72.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three adenocarcinomas that clustered away from the majority of adenocarcinomas (shcx173, shcx172b, and shcx150) were distinguished by significant expression of genes encoding digestive enzymes, such as pancreatic amylase (AMY2A) and elastase (ELA3A), suggesting the presence of normal acinar cells in addition to the neoplastic component.
Gene_expression (expression) of ELA3A in acinar cells associated with adenocarcinoma
1) Confidence 0.62 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.49 Pain Relevance 0
Genes encoding digestive enzymes produced by acinar cells such as amylase (AMY2A), elastase (ELA3A, ELA3B), carboxypeptidase A (CPA2), pancreatic lipase (PNLIP), and trypsin (PRSS2) were enriched in this cluster (Figures 1, “Acinar” cluster).
Gene_expression (produced) of ELA3A in acinar cells
2) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.09 Pain Relevance 0.06

General Comments

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