INT205095

Context Info Confidence 0.62 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.58 Pain Relevance 0.06

peptidase activity (CELA3A)

Anatomy Link Frequency acinar cells 2 CELA3A (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 6 66.64 Somatostatin 2 30.68 Chronic pancreatitis 2 25.88

Disease Link Frequency Relevance Heat Adenocarcinoma 134 98.64 Islet Cell Adenoma 58 91.96 Cancer 82 89.44 Pancreatic Cancer 54 83.36 Lymphatic System Cancer 10 81.20 Liposarcoma 2 78.40 Thyroid Neoplasm 2 77.88 Skin Cancer 2 75.84 Leukemia 4 75.44 Fibrosarcoma 2 72.60

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Anatomy

Negation

Speculation

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Disease term

Three adenocarcinomas that clustered away from the majority of adenocarcinomas (shcx173, shcx172b, and shcx150) were distinguished by significant expression of genes encoding digestive enzymes, such as pancreatic amylase (AMY2A) and elastase (ELA3A), suggesting the presence of normal acinar cells in addition to the neoplastic component.

Gene_expression (expression) of ELA3A in acinar cells associated with adenocarcinoma

1) Confidence 0.62 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.49 Pain Relevance 0

Genes encoding digestive enzymes produced by acinar cells such as amylase (AMY2A), elastase (ELA3A, ELA3B), carboxypeptidase A (CPA2), pancreatic lipase (PNLIP), and trypsin (PRSS2) were enriched in this cluster (Figures 1, “Acinar” cluster).

Gene_expression (produced) of ELA3A in acinar cells

2) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.09 Pain Relevance 0.06

General Comments

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