INT205096

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Context Info
Confidence 0.71
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 21
Disease Relevance 6.06
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LGALS4) cell adhesion (LGALS4) plasma membrane (LGALS4)
Anatomy Link Frequency
epithelial cells 3
HT-29 2
Caco-2 2
lamina 2
T cells 2
LGALS4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 560 100.00 Very High Very High Very High
Inflammation 740 98.84 Very High Very High Very High
cINOD 20 94.92 High High
Adalimumab 40 85.04 High High
Crohn's disease 80 80.44 Quite High
abdominal pain 20 67.00 Quite High
addiction 20 57.12 Quite High
Inflammatory response 20 57.08 Quite High
metalloproteinase 3 43.32 Quite Low
Potency 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 67 99.56 Very High Very High Very High
INFLAMMATION 540 98.84 Very High Very High Very High
Colitis 340 97.00 Very High Very High Very High
Adhesions 20 94.52 High High
Mucositis 200 89.84 High High
Inflammatory Bowel Disease 360 83.76 Quite High
Apoptosis 1080 82.28 Quite High
Disease 190 80.44 Quite High
Death 402 78.64 Quite High
Cancer 81 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, we demonstrated that Gal-4 is secreted by intestinal epithelial cell lines, a pre-requirement to interact with the underlying cells of the lamina propria.
Localization (secreted) of Gal-4 in lamina
1) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.48 Pain Relevance 0.16
Our results systematically and sequentially uncovered the expression and secretion profile of Gal-4 as well as a previously unrecognized biological function of this lectin.
Localization (secretion) of Gal-4
2) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 1.38 Pain Relevance 0.40
To determine if Gal-4 is secreted by epithelial cells, HT-29, and Caco-2 cells were cultured for 48 h after which Gal-4 secretion was determined by a Gal-4 ELISA.
Localization (secreted) of Gal-4 in Caco-2
3) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.05 Pain Relevance 0
Having defined that Gal-4 is strongly expressed in gastrointestinal epithelial cells, we next investigated, if Gal-4 is also secreted by epithelial cells and thus can interact with the underlying T cells in the lamina propria.


Localization (secreted) of Gal-4 in lamina
4) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.17 Pain Relevance 0.03
Galectin-4 secretion
Localization (secretion) of Galectin-4
5) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.25 Pain Relevance 0.10
and IL-10 secretion by Gal-4 underscores the potential therapeutic use of Gal-4 and explains its beneficial effect in experimental colitis.
Localization (secretion) of Gal-4 associated with colitis
6) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 1.53 Pain Relevance 0.41
Thus, to complete the picture, we measured the ability of Gal-4 to modulate cytokine secretion in this model of intestinal inflammation.


Localization (secretion) of Gal-4 associated with inflammation and cytokine
7) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.90 Pain Relevance 0.48
For separation of Gal-4-associated complexes, tosyl-activated supermagnetic polystyrene beads (Dynalbeads; Dynal Biotech) were coated with BSA, Gal-1 (R&D Systems) and Gal-4.
Localization (separation) of Gal-4
8) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.04
Gal-4 was detected by ELISA using an anti-human Galectin-4 capture Ab (R&D Systems) and a biotinylated anti-human Galectin-4 Ab (R&D Systems) and visualized by streptavidin-horseradish peroxidase and TMB substrate (both from BD Pharmingen).


Localization (visualized) of Gal-4
9) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.20 Pain Relevance 0.12
These genes include many not previously associated with pancreatic adenocarcinoma, such as galectin-4 (LGALS4), mucin 13 (MUC13), secretory leukocyte protease inhibitor (SLPI), collagen 17A1 (COL17A1), and ropporin 1-like (ROPN1L).
Localization (secretory) of LGALS4 in leukocyte associated with adenocarcinoma
10) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 0.61 Pain Relevance 0
Here we provide novel evidence that galectin-4 is selectively expressed and secreted by intestinal epithelial cells and binds potently to activated peripheral and mucosal lamina propria T-cells at the CD3 epitope.
Localization (secreted) of galectin-4 in T-cells
11) Confidence 0.62 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2440804 Disease Relevance 0.28 Pain Relevance 0.04
Having defined that Gal-4 is secreted by epithelial cells, we next addressed the question of whether Gal-4 binds to T cells, obligatory to modulate their function.


Localization (secreted) of Gal-4 in epithelial cells
12) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
Gal-4 secretion
Localization (secretion) of Gal-4
13) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.11 Pain Relevance 0.03
To determine if Gal-4 is secreted by epithelial cells, HT-29, and Caco-2 cells were cultured for 48 h after which Gal-4 secretion was determined by a Gal-4 ELISA.
Localization (secretion) of Gal-4 in Caco-2
14) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
Magnetic separation of Gal-4-containing complexes
Localization (separation) of Gal-4
15) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.04
Having demonstrated that Gal-4 substantially inhibits PBT cell cycling, we were interested in whether Gal-4 modulate cytokine release patterns in T cells.
Localization (release) of Gal-4 in T cells associated with cytokine
16) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.19
Constantly, both cell lines secreted within this timeline about 45±6 pg/ml Gal-4.
Localization (secreted) of Gal-4
17) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
To determine if Gal-4 is secreted by epithelial cells, HT-29, and Caco-2 cells were cultured for 48 h after which Gal-4 secretion was determined by a Gal-4 ELISA.
Localization (secreted) of Gal-4 in epithelial cells
18) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.05 Pain Relevance 0
To determine if Gal-4 is secreted by epithelial cells, HT-29, and Caco-2 cells were cultured for 48 h after which Gal-4 secretion was determined by a Gal-4 ELISA.
Localization (secreted) of Gal-4 in HT-29
19) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.05 Pain Relevance 0
To determine if Gal-4 is secreted by epithelial cells, HT-29, and Caco-2 cells were cultured for 48 h after which Gal-4 secretion was determined by a Gal-4 ELISA.
Localization (secretion) of Gal-4 in HT-29
20) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0

General Comments

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