INT205099

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (AXIN2) plasma membrane (AXIN2) nucleus (AXIN2)
intracellular (AXIN2) enzyme binding (AXIN2) cytoplasm (AXIN2)
AXIN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 9 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Islet Cell Adenoma 87 99.84 Very High Very High Very High
Adenocarcinoma 201 99.40 Very High Very High Very High
Cancer 123 98.36 Very High Very High Very High
Gastrointestinal Neoplasms 3 93.00 High High
Pancreatic Cancer 81 81.76 Quite High
Disease 30 63.96 Quite High
Breast Cancer 6 49.20 Quite Low
Syndrome 9 27.84 Quite Low
Multiple Endocrine Neoplasia Type 1 6 27.48 Quite Low
Insulinoma 6 22.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have established that Axin2 expression is induced by Wnt pathway activation and serves as a useful marker.
Positive_regulation (induced) of Gene_expression (expression) of Axin2
1) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.05 Pain Relevance 0
Higher expression of Axin2 in pancreatic adenocarcinomas and islet tumors compared to their non-neoplastic counterparts supports the potential importance of Wnt pathway activation in these tumors.
Positive_regulation (Higher) of Gene_expression (expression) of Axin2 associated with adenocarcinoma and cancer
2) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.12 Pain Relevance 0
AXIN2 expression was also elevated in islet cell tumors, which likely contributed to its clustering away from the previously identified adenocarcinoma gene clusters.
Positive_regulation (elevated) of Gene_expression (expression) of AXIN2 associated with adenocarcinoma and islet cell adenoma
3) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.31 Pain Relevance 0

General Comments

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