INT205105

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (AXIN2) plasma membrane (AXIN2) nucleus (AXIN2)
intracellular (AXIN2) enzyme binding (AXIN2) cytoplasm (AXIN2)
Anatomy Link Frequency
pancreatic duct 1
AXIN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 6 47.04 Quite Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastrointestinal Neoplasms 6 99.92 Very High Very High Very High
Islet Cell Adenoma 174 99.84 Very High Very High Very High
Adenocarcinoma 402 99.40 Very High Very High Very High
Cancer 246 98.36 Very High Very High Very High
Syndrome 18 92.32 High High
Pancreatic Cancer 162 92.16 High High
Multiple Endocrine Neoplasia Type 1 12 91.96 High High
Insulinoma 12 87.04 High High
Neuroendocrine Cancer 12 81.88 Quite High
Breast Cancer 12 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of AXIN2, a marker for Wnt pathway activation [39]–[41], was generally higher in pancreatic adenocarcinomas compared to primary pancreatic duct cells (Figure 5).
Gene_expression (Expression) of AXIN2 in pancreatic duct associated with adenocarcinoma
1) Confidence 0.74 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.22 Pain Relevance 0
Higher expression of Axin2 in pancreatic adenocarcinomas and islet tumors compared to their non-neoplastic counterparts supports the potential importance of Wnt pathway activation in these tumors.
Gene_expression (expression) of Axin2 associated with adenocarcinoma and cancer
2) Confidence 0.74 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.11 Pain Relevance 0
Recent studies have established that Axin2 expression is induced by Wnt pathway activation and serves as a useful marker.
Gene_expression (expression) of Axin2
3) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.05 Pain Relevance 0
Tissue microarrays constructed to evaluate axin2 expression contained 13 normal pancreata and 26 pancreatic adenocarcinomas.
Gene_expression (expression) of axin2 associated with adenocarcinoma
4) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 0.33 Pain Relevance 0
AXIN2 expression was also elevated in islet cell tumors, which likely contributed to its clustering away from the previously identified adenocarcinoma gene clusters.
Gene_expression (expression) of AXIN2 associated with adenocarcinoma and islet cell adenoma
5) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.31 Pain Relevance 0
Our analysis identified additional genes, including AXL, MFAB, and AXIN2, whose elevated expression in islet cell tumors suggests signal transduction pathways important in their development.
Gene_expression (expression) of AXIN2 associated with islet cell adenoma
6) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.59 Pain Relevance 0

General Comments

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