INT205120

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.83
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD4, CD8A) signal transduction (CD4) extracellular region (CD8A)
cell adhesion (CD4) enzyme binding (CD4)
Anatomy Link Frequency
T-cell 3
CD4 (Homo sapiens)
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 110 99.20 Very High Very High Very High
rheumatoid arthritis 8 81.84 Quite High
Inflammation 21 77.52 Quite High
Kinase C 1 45.36 Quite Low
tolerance 3 24.48 Low Low
Pain 1 22.68 Low Low
cytokine 24 11.64 Low Low
corticosteroid 38 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 32 99.46 Very High Very High Very High
Systemic Lupus Erythematosus 6 99.28 Very High Very High Very High
Rheumatoid Arthritis 114 99.20 Very High Very High Very High
Adult T-cell Leukemia-lymphoma 11 98.56 Very High Very High Very High
Autoimmune Disease 17 85.56 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 80.04 Quite High
INFLAMMATION 22 77.52 Quite High
Osteoporosis 3 72.56 Quite High
Hypercalcemia 29 59.44 Quite High
Granuloma 3 57.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 1, no difference was detected in the ratio of CD4+ (p = 0.63) to CD8+ (p = 0.22) T cells between the two groups.
CD4 Binding (ratio) of CD8 in T cells
1) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.09 Pain Relevance 0.32
We conclude that, unlike Systemic Lupus Erythematosus, disease status does not alter the ratio of CD4+ to CD8+ T cell subsets in RA.


CD4 Neg (not) Binding (ratio) of CD8 in T cell associated with disease, systemic lupus erythematosus and arthritis
2) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.16 Pain Relevance 0.36
The strong presence of CD2, CD3, and CD4 coupled with the much weaker immunoreactivity of CD7 and CD8 was consistent with a diagnosis of ATLL.
CD4 Binding (coupled) of CD8 associated with adult t-cell leukemia-lymphoma
3) Confidence 0.04 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC1824742 Disease Relevance 0.51 Pain Relevance 0
The T-cell receptor (TCR) is the antigen-recognition unit on the T-cell surface and associated with molecules such as Cluster of Differentiation 3 (CD3) and either CD4 or CD8 [11].
CD4 Binding (associated) of T-cell receptor in T-cell
4) Confidence 0.02 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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