INT205152

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Context Info
Confidence 0.35
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 17.13
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) cell adhesion (CD44) plasma membrane (CD44)
CD44 (Homo sapiens)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 317 100.00 Very High Very High Very High
Pain 42 79.20 Quite High
Inflammation 62 36.96 Quite Low
Nicotine 20 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
transdermal 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 673 99.60 Very High Very High Very High
Metastasis 365 99.24 Very High Very High Very High
Prostate Cancer 840 99.16 Very High Very High Very High
Breast Cancer 21 98.76 Very High Very High Very High
Carcinoma 69 98.64 Very High Very High Very High
Apoptosis 86 97.92 Very High Very High Very High
Skin Cancer 107 97.84 Very High Very High Very High
Wound Healing 23 95.44 Very High Very High Very High
Hypercalcemia 105 94.84 High High
Adhesions 333 87.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP-9 activity associated with the CD44-immunecomplex was analyzed by zymogram analysis as described in the Methods section.
CD44 Binding (associated) of MMP-9
1) Confidence 0.35 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.36 Pain Relevance 0
CD44 associates with a proteolytic form of the matrix metalloproteinase-9 (MMP-9) on the surface of mouse mammary carcinoma and human melanoma cells.
CD44 Binding (associates) of MMP-9 associated with metalloproteinase, carcinoma and skin cancer
2) Confidence 0.35 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.97 Pain Relevance 0.32
CD44 associates with a proteolytic form of the matrix metalloproteinase-9 (MMP-9) on the surface of mouse mammary carcinoma and human melanoma cells.
CD44 Binding (associates) of metalloproteinase-9 associated with metalloproteinase, carcinoma and skin cancer
3) Confidence 0.31 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.96 Pain Relevance 0.32
MMP-9 activity associated with cell surface CD44 was analyzed by gelatin zymography as described below.
CD44 Binding (associated) of MMP-9
4) Confidence 0.27 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
CD44/MMP-9 complex formation on the cell surface may represent a unique motility-enhancing signal in prostate cancer cells, thereby promoting their invasiveness.


CD44 Binding (formation) of MMP-9 associated with prostate cancer
5) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.15 Pain Relevance 0.15
3 signaling-mediated CD44/MMP-9 complex formation on the cell surface, MMP-9 secretion, and activity may play important roles in prostate cancer cell migration.
CD44 Binding (formation) of MMP-9 associated with prostate cancer
6) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.45 Pain Relevance 0.18
In an attempt to further elucidate that the interaction of CD44 and MMP-9 on the cell surface is specific, we performed immunostaining analysis with an antibody to human Zip-1 (hZip-1).
CD44 Binding (interaction) of MMP-9
7) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.08 Pain Relevance 0
These observations suggest that CD44/MMP-9 interaction on the cell surface has a role in tumor progression [19].
CD44 Binding (interaction) of MMP-9 associated with cancer
8) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.69 Pain Relevance 0.04
In the present study, we show that the surface expression of CD44 and the interaction of CD44 with MMP-9 was reduced in PC3/OPN (RGA) cells as compared with PC3 and PC3/OPN cells (Figures 2, 3, and 5).
CD44 Binding (interaction) of MMP-9
9) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.68 Pain Relevance 0.07
The effect of BPs on the surface interaction of CD44 and MMP-9 was analyzed by immunostaining analysis with respective antibodies in cells that were neither fixed with paraformaldehyde nor permeablized with Triton X-100 (Figure 5).
CD44 Binding (interaction) of MMP-9
10) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.21 Pain Relevance 0
We show here the inhibitory effect of bisphosphonates (e.g. alendronate and pamidronate) on MMP-9 activity, CD44 surface expression, cell surface CD44/MMP-9 interaction, and migration (Figs. 4 and 5); without increasing apoptosis of cells.
CD44 Binding (interaction) of MMP-9 associated with apoptosis
11) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.51 Pain Relevance 0.08
Attenuation of Rho GTPase activation by BPs may have contributed to the down regulation of cell surface CD44/MMP-9 interaction, MMP-9 activation/secretion, and cell migration.
CD44 Binding (interaction) of MMP-9
12) Confidence 0.26 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1828067 Disease Relevance 0.16 Pain Relevance 0
The effects of BPs on the surface interaction of MMP-9 and CD44
CD44 Binding (interaction) of MMP-9
13) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.26 Pain Relevance 0.03
Active MMP-9 has been found in association with the vCD44 isoform on the invadopodia of breast cancer cells [33,46,49].
vCD44 Binding (association) of MMP-9 associated with breast cancer
14) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.68 Pain Relevance 0.04
These observations suggest that CD44/MMP-9 interaction on the cell surface has a role in tumor progression [19].
CD44 Binding (interaction) of MMP-9 associated with cancer
15) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.69 Pain Relevance 0.04
3 signaling-mediated CD44/MMP-9 complex formation on the cell surface, MMP-9 secretion, and activity may play important roles in prostate cancer cell migration.
CD44 Binding (formation) of MMP-9 associated with prostate cancer
16) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.45 Pain Relevance 0.18
We show here the inhibitory effect of bisphosphonates (e.g. alendronate and pamidronate) on MMP-9 activity, CD44 surface expression, cell surface CD44/MMP-9 interaction, and migration (Figs. 4 and 5); without increasing apoptosis of cells.
CD44 Binding (interaction) of MMP-9 associated with apoptosis
17) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.51 Pain Relevance 0.08
Attenuation of Rho GTPase activation by BPs may have contributed to the down regulation of cell surface CD44/MMP-9 interaction, MMP-9 activation/secretion, and cell migration.
CD44 Binding (interaction) of MMP-9
18) Confidence 0.26 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1828067 Disease Relevance 0.16 Pain Relevance 0
CD44/MMP-9 complex formation on the cell surface may represent a unique motility-enhancing signal in prostate cancer cells, thereby promoting their invasiveness.


CD44 Binding (formation) of MMP-9 associated with prostate cancer
19) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.15 Pain Relevance 0.15
Stripping and reprobing of the above blot with an antibody to MMP-9 demonstrated the levels of MMP-9 interaction with CD44 (Figure 3C).
CD44 Binding (interaction) of MMP-9
20) Confidence 0.23 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0

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