INT205155

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.98
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) cell adhesion (CD44) plasma membrane (CD44)
CD44 (Homo sapiens)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 45 84.16 Quite High
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 12 97.92 Very High Very High Very High
Skin Cancer 15 95.72 Very High Very High Very High
Breast Cancer 3 91.36 High High
Cancer 93 88.00 High High
Metastasis 51 86.84 High High
Prostate Cancer 120 85.56 High High
Carcinoma 9 78.08 Quite High
Adhesions 21 75.08 Quite High
Severe Combined Immunodeficiency 3 73.36 Quite High
Advanced Or Metastatic Breast Cancer 3 64.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here the inhibitory effect of bisphosphonates (e.g. alendronate and pamidronate) on MMP-9 activity, CD44 surface expression, cell surface CD44/MMP-9 interaction, and migration (Figs. 4 and 5); without increasing apoptosis of cells.
Negative_regulation (effect) of CD44 Binding (interaction) of MMP-9 associated with apoptosis
1) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.52 Pain Relevance 0.08
In the present study, we show that the surface expression of CD44 and the interaction of CD44 with MMP-9 was reduced in PC3/OPN (RGA) cells as compared with PC3 and PC3/OPN cells (Figures 2, 3, and 5).
Negative_regulation (reduced) of CD44 Binding (interaction) of MMP-9
2) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.68 Pain Relevance 0.07
A decrease in MMP-9 interaction with CD44 on the cell surface and secretion of MMP- 9 suggests a role for integrin ?
Negative_regulation (decrease) of CD44 Binding (interaction) of MMP-9
3) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.78 Pain Relevance 0.07

General Comments

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