INT205159

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.80
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SPP1, TNFSF11) extracellular region (SPP1, TNFSF11) cytoplasm (SPP1, TNFSF11)
cell differentiation (TNFSF11) cell adhesion (SPP1) plasma membrane (TNFSF11)
Anatomy Link Frequency
osteoclasts 2
SPP1 (Homo sapiens)
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 30 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genomic Instability 2 96.20 Very High Very High Very High
Metastasis 34 94.56 High High
Cancer 62 93.44 High High
Prostate Cancer 80 87.36 High High
Renal Disease 2 73.88 Quite High
Adenocarcinoma 2 72.00 Quite High
Adhesions 14 66.24 Quite High
Injury 28 5.00 Very Low Very Low Very Low
Hypercalcemia 10 5.00 Very Low Very Low Very Low
Skin Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The addition of OPN increased the expression of RANKL and augmented the differentiation of osteoclasts from OPN deficient mice [37].
OPN Positive_regulation (increased) of Gene_expression (expression) of RANKL in osteoclasts
1) Confidence 0.11 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.24 Pain Relevance 0
These observations are in keeping with the observation of Ishi et al., that OPN increased the expression of RANKL [37].



OPN Positive_regulation (increased) of Gene_expression (expression) of RANKL
2) Confidence 0.09 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.56 Pain Relevance 0

General Comments

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