INT205171

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.94
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TNFSF11) extracellular space (TNFSF11) extracellular region (TNFSF11)
plasma membrane (TNFSF11) intracellular (TNFSF11) response to stress (TNFSF11)
Anatomy Link Frequency
osteoblasts 1
osteoclasts 1
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 66 99.30 Very High Very High Very High
Pain 5 96.48 Very High Very High Very High
cytokine 16 88.56 High High
withdrawal 1 69.76 Quite High
metalloproteinase 17 47.60 Quite Low
antagonist 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 57 99.60 Very High Very High Very High
Osteoarthritis 66 99.30 Very High Very High Very High
Cancer 99 97.04 Very High Very High Very High
Pain 5 96.48 Very High Very High Very High
Osteolysis 16 94.80 High High
Hypercalcemia 25 94.12 High High
Metastasis 110 93.28 High High
Breast Cancer 16 91.16 High High
Osteoporosis 89 88.16 High High
Lifespan 2 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously demonstrated that OA subchondral bone osteoblasts can be discriminated into two subgroups and that both OPG and RANKL expression levels, and consequently the expression ratio of OPG/RANKL, differ according to the metabolic state of human OA subchondral bone osteoblasts: OPG/RANKL is decreased in L- and increased in H-OA osteoblasts[11].
Localization (decreased) of RANKL in osteoblasts associated with osteoarthritis
1) Confidence 0.74 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.95 Pain Relevance 0.40
Experiments in our laboratory and others have demonstrated increased secretion of soluble RANKL by human prostate cancer cells, forming osteolytic lesions [28,42,43].
Localization (secretion) of RANKL associated with prostate cancer
2) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.11 Pain Relevance 0.04
Estradiol appears to decrease the responsiveness of osteoclasts to factors such as receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage-colony stimulating factor (M-CSF), released in the bone microenvironment by osteogenic cells and by marrow stroma (Hughes et al 1996; Taranta et al 2002).
Localization (released) of RANKL in osteoclasts
3) Confidence 0.31 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.66 Pain Relevance 0.12
Prostate cancer cells in bone have been shown to secrete factors such as, PTHrP and RANKL [57-59].
Localization (secrete) of RANKL associated with prostate cancer
4) Confidence 0.23 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.22 Pain Relevance 0.10

General Comments

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