INT205187

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.11
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (TBCE) cytoskeleton (TBCE) cytoplasm (TBCE)
Anatomy Link Frequency
eye 1
leukocyte 1
hepatocytes 1
KCs 1
TBCE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 245 99.60 Very High Very High Very High
agonist 162 99.60 Very High Very High Very High
Inflammatory mediators 9 99.48 Very High Very High Very High
cytokine 148 99.36 Very High Very High Very High
chemokine 30 97.40 Very High Very High Very High
Inflammatory response 46 87.60 High High
tolerance 21 85.76 High High
ischemia 12 76.16 Quite High
Bile 81 64.68 Quite High
Neurotransmitter 1 37.76 Quite Low
Disease Link Frequency Relevance Heat
Disorders Of The Lacrimal System 25 100.00 Very High Very High Very High
INFLAMMATION 287 99.60 Very High Very High Very High
Dry Eye 74 99.28 Very High Very High Very High
Congenital Anomalies 2 98.68 Very High Very High Very High
Ocular Injury 4 93.28 High High
Infection 36 91.68 High High
Hepatitis C Virus Infection 30 91.28 High High
Pruritus 2 85.56 High High
Hepatitis 16 84.72 Quite High
Targeted Disruption 3 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, CsA for treating KCS in patients with dry eye was evaluated in large multi-center randomized double-masked FDA clinical trials.
Localization (treating) of KCS in eye associated with disorders of the lacrimal system and dry eye
1) Confidence 0.14 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699789 Disease Relevance 0.77 Pain Relevance 0
By contrast, freshly isolated human KCs secrete the anti-inflammatory cytokine IL-10 in response to stimulation with LPS, which contributes to the downregulation of pro-inflammatory cytokines.
Localization (secrete) of KCs associated with inflammation, agonist and cytokine
2) Confidence 0.12 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.08 Pain Relevance 0.92
LPS stimulates TLR4 on KCs to enhance hepatocyte damage, increase leukocyte infiltration and secrete pro-fibrogenic cytokines.
Localization (secrete) of KCs in leukocyte associated with agonist and cytokine
3) Confidence 0.10 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.13 Pain Relevance 0.89
KCs also secrete various pro-inflammatory mediators including cytokines, prostanoids, nitric oxide and reactive oxygen intermediates.
Localization (secrete) of KCs in KCs associated with inflammatory mediators and cytokine
4) Confidence 0.10 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.05 Pain Relevance 0.63
Even though the majority of cells that took up reporter gene (or particles) were hepatocytes, we observed a significantly higher level of DNA co-localization with KCs in the PEI-group (Figures 6e, g), compared with chitosan-group and naked DNA group.
Localization (localization) of KCs in hepatocytes
5) Confidence 0.04 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC1828073 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox