INT205189

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 9.67
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (TBCE) cytoskeleton (TBCE) cytoplasm (TBCE)
Anatomy Link Frequency
eye 3
hepatocytes 3
macrophages 1
TBCE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 97.92 Very High Very High Very High
Bile 198 97.12 Very High Very High Very High
Neurotransmitter 4 94.28 High High
Analgesic 1 85.84 High High
anesthesia 26 76.80 Quite High
Inflammatory response 6 75.92 Quite High
addiction 1 69.04 Quite High
dexamethasone 3 62.04 Quite High
Inflammatory mediators 2 34.68 Quite Low
cytokine 12 31.24 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 379 100.00 Very High Very High Very High
Dry Eye 260 100.00 Very High Very High Very High
Sjoegrens Syndrome 193 100.00 Very High Very High Very High
Disorders Of The Lacrimal System 34 100.00 Very High Very High Very High
Eye Disease 73 99.80 Very High Very High Very High
Sicca Syndrome 10 99.80 Very High Very High Very High
INFLAMMATION 72 97.92 Very High Very High Very High
Hepatitis 5 96.32 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 8 95.88 Very High Very High Very High
Epilepsy 1 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that Sjogren’s subjects express significantly elevated concentrations of both soluble MUC1 and MUC1 mRNA compared to both KCS and NDE groups.
Gene_expression (express) of KCS associated with sjoegrens syndrome and dry eye
1) Confidence 0.25 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.28 Pain Relevance 0
MUC1 expression in Sjogren’s syndrome, KCS, and control subjects

Purpose

Gene_expression (expression) of KCS associated with syndrome
2) Confidence 0.19 Published 2010 Journal Molecular Vision Section Title Doc Link PMC2927371 Disease Relevance 1.19 Pain Relevance 0
No differences were found in MUC16 expression between the KCS and NDE subjects.
Gene_expression (expression) of KCS associated with sjoegrens syndrome and eye disease
3) Confidence 0.15 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.85 Pain Relevance 0
We found that Sjogren’s subjects express significantly elevated concentrations of both soluble MUC16 and MUC16 mRNA compared to both KCS and NDE groups.
Gene_expression (express) of KCS associated with sjoegrens syndrome and eye disease
4) Confidence 0.15 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.86 Pain Relevance 0
The potential of CsA for treating dry eye syndrome and its clinical expression KCS was initially tested in 1989 in dogs affected with spontaneous canine KCS.
Gene_expression (expression) of KCS in eye associated with disorders of the lacrimal system and dry eye
5) Confidence 0.14 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699789 Disease Relevance 1.16 Pain Relevance 0.03
Our KCS group had Schirmer test confirmed reduced aqueous secretions and thus we were able to compare the two well defined aqueous deficient groups as stated in the DEWS 2007 definition of dry eye [28].
Gene_expression (group) of KCS in eye associated with sicca syndrome, sjoegrens syndrome and dry eye
6) Confidence 0.13 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.92 Pain Relevance 0
MUC16 expression in Sjogren’s syndrome, KCS, and control subjects

Purpose

Gene_expression (expression) of KCS associated with syndrome
7) Confidence 0.12 Published 2008 Journal Molecular Vision Section Title Doc Link PMC2613075 Disease Relevance 1.07 Pain Relevance 0.08
The results of this study demonstrate that subjects with confirmed Sjogren’s Syndrome display a significant increase in MUC16 expression, as the concentrations of both MUC16 soluble protein and mRNA were found to be higher than those of aqueous deficient dry eye subjects (KCS) and subjects with no dry eye disease (NDE).
Gene_expression (expression) of KCS in eye associated with sjoegrens syndrome, syndrome, dry eye and eye disease
8) Confidence 0.12 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.15 Pain Relevance 0
Furthermore, the elimination of KCs by clodronate-encapsulated liposomes was recently shown to provoke non-alcoholic steatotic hepatitis (NASH) due to the concomitant elimination of protective IL-10.9 Paradoxically, other models using gadolinium chloride to eliminate KCs have shown that this procedure improved insulin resistance and NASH induced by high fat10 or S, one of the primary sources of F.11 TNF?
Gene_expression (elimination) of KCs associated with nash(non-alcoholic steatohepatitis), insulin resistance and hepatitis
9) Confidence 0.06 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 0.57 Pain Relevance 0.04
Transfection of primary rat hepatocytes, KCs, and normal rat cholangiocytes (NRCs)
Gene_expression (Transfection) of KCs in hepatocytes
10) Confidence 0.04 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC1828073 Disease Relevance 0 Pain Relevance 0.39
PEI-DNA nanoparticles were more efficient, resulting in 26, 43, and 25 times higher luciferase expression than chitosan-DNA nanoparticles in transfecting hepatocytes, NRCs, and KCs, respectively.
Gene_expression (transfecting) of KCs in hepatocytes
11) Confidence 0.03 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC1828073 Disease Relevance 0 Pain Relevance 0.28
Transfection of primary rat hepatocytes, KCs, and NRCs
Gene_expression (Transfection) of KCs in hepatocytes
12) Confidence 0.03 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC1828073 Disease Relevance 0 Pain Relevance 0.07
2A-receptor subtype expressed on hepatic macrophages (i.e., KCs) can now be added to this list.
Gene_expression (expressed) of KCs in macrophages
13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677660 Disease Relevance 0.62 Pain Relevance 0.30

General Comments

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