INT205196

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 12.19
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar2) signal transducer activity (Lpar2)
Anatomy Link Frequency
epithelial cells 4
lung 2
Neuronal 1
neurons 1
TSCs 1
Lpar2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 198 99.84 Very High Very High Very High
dorsal root ganglion 70 99.68 Very High Very High Very High
Kinase C 48 95.60 Very High Very High Very High
Hippocampus 24 93.28 High High
allodynia 36 91.20 High High
Inflammation 101 91.12 High High
antagonist 52 90.32 High High
Thermal hyperalgesia 15 90.20 High High
chemokine 34 90.08 High High
Glutamate 118 90.00 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 162 100.00 Very High Very High Very High
Aids-related Complex 214 99.90 Very High Very High Very High
Ovarian Cancer 72 99.86 Very High Very High Very High
Targeted Disruption 134 99.84 Very High Very High Very High
Ganglion Cysts 114 99.68 Very High Very High Very High
Hematological Disease 14 99.16 Very High Very High Very High
Acute-phase Reaction 6 98.40 Very High Very High Very High
Breast Cancer 55 97.96 Very High Very High Very High
Hypotrichosis 9 95.36 Very High Very High Very High
Syndrome 4 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result is consistent with previous reports suggesting that LPA2 and LPA3 receptors might contribute to LPA-induced LPA production in ovarian cancer cells, because ovarian cancer cells express high levels of LPA2 and LPA3 receptors whereas normal ovarian epithelial cells express low levels of LPA2 and LPA3 receptors [41-43].
Gene_expression (express) of LPA2 in epithelial cells associated with ovarian cancer
1) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.45 Pain Relevance 0.34
This result is consistent with previous reports suggesting that LPA2 and LPA3 receptors might contribute to LPA-induced LPA production in ovarian cancer cells, because ovarian cancer cells express high levels of LPA2 and LPA3 receptors whereas normal ovarian epithelial cells express low levels of LPA2 and LPA3 receptors [41-43].
Gene_expression (express) of LPA2 in epithelial cells associated with ovarian cancer
2) Confidence 0.64 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.47 Pain Relevance 0.35
Ovarian cancers predominantly express LPA2 receptors, whereas this receptor is barely detected in ovarian epithelial cells (Goetzl et al., 1999a).
Gene_expression (express) of LPA2 in epithelial cells associated with ovarian cancer
3) Confidence 0.60 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 1.33 Pain Relevance 0.07
This result is consistent with previous reports suggesting that LPA2 and LPA3 receptors might contribute to LPA-induced LPA production in ovarian cancer cells, because ovarian cancer cells express high levels of LPA2 and LPA3 receptors whereas normal ovarian epithelial cells express low levels of LPA2 and LPA3 receptors [41-43].
Gene_expression (express) of LPA2 in epithelial cells associated with ovarian cancer
4) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.47 Pain Relevance 0.35
Finally, it should be noted that LPA-induced de novo LPC (or converted LPA) synthesis in SC and DR was completely absent in Lpar3-/- mice, but not in Lpar1-/- and Lpar2-/- mice, though LPA1, LPA2 and LPA3 receptors were all expressed in SC and DR.
Gene_expression (expressed) of LPA2 associated with spinal cord
5) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.45 Pain Relevance 0.38
On the other hand, three kinds of LPA1, LPA2 and LPA3 receptors were all expressed in SC and DR by RT-PCR, though the level of LPA1 transcripts was much higher than the others (Additional file 2; Fig.
Gene_expression (expressed) of LPA2 associated with spinal cord
6) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.10 Pain Relevance 0.44
In addition to LPA2, LPA4 is highly expressed in normal ovarian tissues (Noguchi et al., 2003).
Gene_expression (expressed) of LPA2
7) Confidence 0.52 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 1.23 Pain Relevance 0.08
Lipase H is the human orthologue of the PA-PLA1 enzyme that produces sn2-LPA from PA.
Gene_expression (produces) of sn2-LPA
8) Confidence 0.47 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.61 Pain Relevance 0.03
Increased expression of LPA2 and LPA3 receptors correlates with late stages of ovarian cancers, whereas expression of LPA1 receptor links to the inhibition of the progression of ovarian tumors.
Gene_expression (expression) of LPA2 associated with ovarian cancer
9) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.52 Pain Relevance 0
Neither LPA2 nor S1P2 was detectable, although S1P3 was expressed in SCs in vivo and in vitro [23].
Gene_expression (detectable) of LPA2
10) Confidence 0.40 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0.21 Pain Relevance 0
Neither LPA2 nor S1P5 was detectable in either type of Schwann cell.
Gene_expression (detectable) of LPA2 in Schwann cell
11) Confidence 0.40 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0 Pain Relevance 0
By using our previously reported method of selectively and efficiently collecting TSCs, we have analyzed the difference in expression patterns of lysophospholipid (LPL) receptor genes (LPA1, LPA2, LPA3, S1P1, S1P2, S1P3, S1P4, and S1P5) between TSCs and myelinating Schwann cells (MSCs).
Spec (analyzed) Gene_expression (expression) of LPA2 in TSCs
12) Confidence 0.31 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1828080 Disease Relevance 0.09 Pain Relevance 0
Among the six LPA receptors, LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6, LPA1 receptor is the main subtype expressed in the DRG neurons [11].
Gene_expression (expressed) of LPA2 in neurons associated with dorsal root ganglion
13) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.79 Pain Relevance 0.88
Thus, our objective was to characterize lung gene expression in two genetically distinct mouse strains, A/J and B6, exposed to either MS or SS welding fume in a comprehensive manner using microarray and IPA.
Gene_expression (expression) of IPA in lung associated with sprains and strains
14) Confidence 0.08 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 0.96 Pain Relevance 0.11
, which regulates the acute phase response, was also downregulated at this time point.

16 weeks post-exposure to GMA-MS: IPA analysis

Gene_expression (analysis) of IPA associated with acute-phase reaction and aids-related complex
15) Confidence 0.08 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.05 Pain Relevance 0
These findings suggest that this particular gene subset may be important in the lung response to toxic stimuli.

4 weeks post-exposure to GMA-SS: IPA analysis

Gene_expression (analysis) of IPA in lung associated with aids-related complex
16) Confidence 0.08 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.04 Pain Relevance 0.12
Neuronal growth, differentiation and preservation of synaptic transmission were also reflected in the GO categories, IPA bio-functions and canonical pathways that were enriched with genes differentially expressed in Tg mice.
Gene_expression (expressed) of IPA in Neuronal associated with targeted disruption
17) Confidence 0.06 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.36 Pain Relevance 0.32
Indeed, IPA positioned TPH2 within the top hematological disease pathway containing 12 candidate genes.
Gene_expression (positioned) of IPA associated with hematological disease
18) Confidence 0.04 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.84 Pain Relevance 0.04
Recall that an Ingenuity Pathways Analysis (IPA) of the 20 IWGCNA candidate genes and the TPH2 gene produced a top IPA network that included the TPH2 gene.
Gene_expression (produced) of IPA
19) Confidence 0.03 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.22 Pain Relevance 0

General Comments

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