INT205198

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 7.35
Pain Relevance 6.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Lpar1) cytoplasm (Lpar1) signal transducer activity (Lpar1)
Anatomy Link Frequency
neurons 3
peripheral nerves 1
nociceptors 1
SCs 1
Lpar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 36 99.58 Very High Very High Very High
Kinase C 222 99.52 Very High Very High Very High
Demyelination 12 99.48 Very High Very High Very High
nav1.8 12 99.26 Very High Very High Very High
Thermal hyperalgesia 30 99.24 Very High Very High Very High
Neuropathic pain 60 98.96 Very High Very High Very High
dorsal root ganglion 318 98.76 Very High Very High Very High
allodynia 30 98.74 Very High Very High Very High
antagonist 36 98.72 Very High Very High Very High
Pain 54 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bone Cancer 258 99.68 Very High Very High Very High
Demyelinating Disease 12 99.48 Very High Very High Very High
Hyperalgesia 30 99.24 Very High Very High Very High
Neuropathic Pain 96 98.96 Very High Very High Very High
Ganglion Cysts 324 98.76 Very High Very High Very High
Nociception 30 98.60 Very High Very High Very High
Pain 66 98.40 Very High Very High Very High
Ovarian Cancer 6 92.60 High High
Cancer 198 90.12 High High
Metastasis 6 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, lines of study have revealed that LPA may also be a crucial factor in the initiation of neuropathic pain mediated by demyelination of peripheral nerves via activation of LPA receptor [11,12].
Positive_regulation (activation) of LPA receptor in peripheral nerves associated with demyelination and neuropathic pain
1) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.64 Pain Relevance 0.53
To investigate the functional significance of activation of LPA1 in the bone cancer state, LPA1 antagonist VPC32183 was used to examine roles of LPA in bone cancer pain.
Spec (investigate) Positive_regulation (activation) of LPA1 associated with cancer pain, antagonist and bone cancer
2) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.07 Pain Relevance 0.70
LPA failed to potentiate TRPV1 currents in all of the neurons tested after incubated with LPA1 antagonist VPC32183 for 30 min (n = 15) (Figure 5A, F, p > 0.05), suggesting that activation of LPA1 receptor mediates LPA-induced potentiation of TRPV1 currents.
Positive_regulation (activation) of LPA1 receptor in neurons associated with antagonist
3) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.59 Pain Relevance 0.75
Collectively, two most important pain-related signal molecules, TRPV1 and Nav1.8, in nociceptors can be modulated by activation of LPA1 mainly via PKC?
Positive_regulation (activation) of LPA1 in nociceptors associated with pain, kinase c, nociceptor and nav1.8
4) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.82 Pain Relevance 1.40
Consistent with alleviation of neuropathic pain [11], VPC32183, a LPA1 and LPA3 receptors antagonist, blocked LPA-induced potentiation of TRPV1 currents in DRG neurons, mechanical allodynia and thermal hyperalgesia in bone cancer rats, suggesting that activation of LPA1 receptors mediates bone cancer-induced sensitization of DRG nociceptive neurons and pain hypersensitization.
Positive_regulation (activation) of LPA1 in neurons associated with nociception, pain, dorsal root ganglion, allodynia, neuropathic pain, antagonist, thermal hyperalgesia and bone cancer
5) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 2.05 Pain Relevance 1.33
, but not PKA, phosphorylation may be a common mechanism in which activation of LPA1 and NK-1 potentiates TRPV1 in DRG nociceptive neurons contributing to bone cancer pain and neuropathic pain.
Positive_regulation (activation) of LPA1 in neurons associated with nociception, dorsal root ganglion, cancer pain, neuropathic pain and bone cancer
6) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.01 Pain Relevance 1.56
Especially, Weiner and Chun demonstrated that LPA1 was expressed by postnatal SCs, and that LPA promotes SC survival via LPA1 activation and a pathway including Gi, PI3K (phosphoinositide-3-kinase) and Akt [23].
Positive_regulation (activation) of LPA1 in SCs
7) Confidence 0.15 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0.16 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox