INT205203
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The findings that co-localization of TRPV1 and LPA1 receptor EDG-2 and bone cancer induced an increase in LPA1 receptor expression in DRG [40] provide further support for these phenomena. | |||||||||||||||
| |||||||||||||||
|
As shown in Figure 2 a large population of DRG neurons expressed TRPV1 (red) and EDG-2 (green). | |||||||||||||||
| |||||||||||||||
|
Among the six subtypes, LPA1 receptor is the main subtype expressed in dorsal root ganglion (DRG) [11]. | |||||||||||||||
| |||||||||||||||
|
TRPV1 and EDG-2 were widely co-expressed in DRG neurons (orange). | |||||||||||||||
| |||||||||||||||
|
Among the six LPA receptors, LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6, LPA1 receptor is the main subtype expressed in the DRG neurons [11]. | |||||||||||||||
| |||||||||||||||
|
Among the six LPA receptors, LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6, LPA1 receptor is the main subtype expressed in the DRG neurons [11]. | |||||||||||||||
| |||||||||||||||
|
Given expression of LPA1 and TRPV1 in the DRG neurons, the present study focused on whether LPA1 is involved in bone cancer pain via cross-talking with TRPV1 and the possible signal pathways in the peripheral mechanism underlying bone cancer pain.
| |||||||||||||||
| |||||||||||||||
|
Inhibition of the LPA1 receptor or synthesis of LPA may be a novel therapy for cancer pain.
| |||||||||||||||
| |||||||||||||||
|
Amongst six subtypes LPA1-6, LPA1 receptors is the main subtype expressed in DRG neurons and activated under the neuropathic pain state [11,15,44]. | |||||||||||||||
| |||||||||||||||
|
Weiner and Chun studied the expression of LPL receptors in Schwann cells (SC) in vivo and in vitro using total RNA by Northern blot analysis, and reported that LPA1 was expressed at high level by SCs in vivo and in vitro, whereas S1P1 was only expressed in SCs in vivo. | |||||||||||||||
| |||||||||||||||
|
Especially, Weiner and Chun demonstrated that LPA1 was expressed by postnatal SCs, and that LPA promotes SC survival via LPA1 activation and a pathway including Gi, PI3K (phosphoinositide-3-kinase) and Akt [23]. | |||||||||||||||
| |||||||||||||||
|
The first lysophosphatidic acid (LPA) receptor gene identified was the ventricular zone gene-1 (vzg-1/LPA1), which was abundantly expressed in the ventricular zone of the embryonic cerebral cortex [3]. | |||||||||||||||
| |||||||||||||||
|
Other types of LPL receptor genes, including LPA1, S1P2, S1P3, and S1P4, were expressed in both types of Schwann cells. | |||||||||||||||
| |||||||||||||||
|
By using our previously reported method of selectively and efficiently collecting TSCs, we have analyzed the difference in expression patterns of lysophospholipid (LPL) receptor genes (LPA1, LPA2, LPA3, S1P1, S1P2, S1P3, S1P4, and S1P5) between TSCs and myelinating Schwann cells (MSCs). | |||||||||||||||
| |||||||||||||||
|
Other types of LPL receptor genes, including LPA1, S1P2, S1P3, S1P4, were expressed in both types of Schwann cells. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.