INT205205

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.27
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn4) plasma membrane (Cldn4) molecular_function (Cldn4)
Anatomy Link Frequency
epithelial cells 2
Cldn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 196 99.68 Very High Very High Very High
cytokine 14 50.76 Quite High
imagery 7 28.84 Quite Low
anesthesia 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 168 99.68 Very High Very High Very High
Reperfusion Injury 147 99.32 Very High Very High Very High
Cv General 4 Under Development 28 85.48 High High
Necrosis 7 31.04 Quite Low
Disseminated Intravascular Coagulation 14 13.72 Low Low
Enteropathy 7 5.00 Very Low Very Low Very Low
Body Weight 7 5.00 Very Low Very Low Very Low
Sepsis 7 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the changes in claudin-4 expression were significantly different from those in other tight-junction proteins, morphometric analysis of claudin-4 expression was performed.
Regulation (changes) of Gene_expression (expression) of claudin-4
1) Confidence 0.42 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Changes in claudin-4 expression during ischemia-reperfusion injury
Regulation (Changes) of Gene_expression (expression) of claudin-4 associated with reperfusion injury and ischemia
2) Confidence 0.42 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.20 Pain Relevance 0.05
Compared with the control samples, the fluorescence intensity of claudin-4 expression appeared increased at both villi and crypts and the expression was not localized to the tips of the villi but was extensively distributed on the villous epithelia (Fig. 3D3, Fig. 5C, 5H, 5M).
Regulation (intensity) of Gene_expression (expression) of claudin-4
3) Confidence 0.31 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.12 Pain Relevance 0.03
Regarding the different patterns of changes of claudin-4 expression in the crypts and in the villi, we conjecture that the cells that survived the ischemia-reperfusion injury in the crypts were converted to overexpression of claudin-4 and migrated upwards to cover the apical surface.
Regulation (changes) of Gene_expression (expression) of claudin-4 associated with reperfusion injury and ischemia
4) Confidence 0.31 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.43 Pain Relevance 0.11
Because we found that changes in claudin-4 expression were significantly different from those in other tight-junction proteins, we also performed morphometric analysis of claudin-4 expression.


Regulation (changes) of Gene_expression (expression) of claudin-4
5) Confidence 0.18 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.52 Pain Relevance 0.18
Four separated crypts which were sliced as cross-sections and situated just above the muscularis mucosae were manually enclosed to measure the claudin-4 expression.
Regulation (measure) of Gene_expression (expression) of claudin-4
6) Confidence 0.18 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Nine to thirteen epithelial cells, which were aligned but not overlapping each other, were manually enclosed to measure the claudin-4 expression.
Regulation (measure) of Gene_expression (expression) of claudin-4 in epithelial cells
7) Confidence 0.18 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0

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