INT205206

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 3.40
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn2) plasma membrane (Cldn2)
Anatomy Link Frequency
epithelial cells 4
Caco-2 2
surface epithelium 1
ileum 1
blood 1
Cldn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 452 99.30 Very High Very High Very High
Inflammation 19 28.32 Quite Low
cytokine 34 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
anesthesia 17 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 337 99.68 Very High Very High Very High
Cv Unclassified Under Development 386 99.30 Very High Very High Very High
Pancreatitis 80 97.64 Very High Very High Very High
Apoptosis 18 84.56 Quite High
Cv General 4 Under Development 66 75.20 Quite High
Enteropathy 16 64.96 Quite High
Injury 19 56.76 Quite High
Necrosis 16 38.84 Quite Low
Inflammatory Bowel Disease 18 28.32 Quite Low
Stress 18 11.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, claudin-2 expression was observed over the whole surface of the villi at 24 hr post-reperfusion.
Gene_expression (expression) of claudin-2
1) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry using control sections of rat ileum demonstrated the expression of claudin-1, claudin-2, claudin-3, claudin-4, claudin-5, ZO-1, and occludin.
Gene_expression (expression) of claudin-2 in ileum
2) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.57 Pain Relevance 0.13
In the control sample, no claudin-2 expression was observed at the tips of the villi.
Gene_expression (expression) of claudin-2
3) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
We have shown that changes in claudin-2 expression are also unique to the period during recovery of epithelium.
Gene_expression (expression) of claudin-2 in epithelium
4) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Accordingly, the claudin-2 expression observed over the whole surface of the villi at 24 hr post-reperfusion in this study suggests that villous epithelial cells are not fully differentiated at 24 hr post-reperfusion.
Gene_expression (expression) of claudin-2 in epithelial cells
5) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Claudin-1, claudin-2, claudin-3, claudin-5, ZO-1, and occludin expression was observed in the recovering epithelium, but the reticular pattern was partly disrupted and irregular at the apical surfaces.
Gene_expression (expression) of claudin-2 in epithelium
6) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.29 Pain Relevance 0.07
Nevertheless, we cannot deny the possibility that claudin-2 expression over the whole surface of the villi at 24 hr post-reperfusion affects tight junctional barrier function including TER.
Gene_expression (expression) of claudin-2
7) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.26 Pain Relevance 0.06
Our results for the claudin-2 expression in the control intestine are congruent with those reported by Escaffit et al. [4], who demonstrated that claudin-2 was detected in both crypts and villus cells of the small intestine but was restricted to undifferentiated crypt cells in the colon.
Gene_expression (expression) of claudin-2 in intestine
8) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Because they found significant reduction of TER but no difference in the paracellular flux of either FITC-dextran-4 kDa or -40 kDa after the addition of claudin-2, it is not likely that the claudin-2 expression observed over the entire surface of the villi at 24 hr post-reperfusion in this study had major effects on changes in the intestinal mucosa-to-blood permeability measured by FITC-dextran-40 kDa.
Gene_expression (expression) of claudin-2 in blood
9) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
They also showed that in the colonic Caco-2 cell model, claudin-2 was found to be present only in undifferentiated cells.
Gene_expression (present) of claudin-2 in Caco-2
10) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
However, claudin-2 expression was observed on the villous surface but the decremental gradient from the crypts to the tips of the villi seen in the control samples was not observed (Fig. 3B4, Fig. 4D1, D2).
Gene_expression (expression) of claudin-2
11) Confidence 0.27 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.22 Pain Relevance 0.05
The decremental gradient of claudin-2 similar to that noted in the control sample was observed at 48 hr post-reperfusion, but claudin-2 expression still remained at the tips of the villi (Fig. 4E1, E2).
Gene_expression (expression) of claudin-2
12) Confidence 0.24 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.16 Pain Relevance 0.04
They also showed that in the colonic Caco-2 cell model, claudin-2 was found to be present only in undifferentiated cells.
Gene_expression (found) of claudin-2 in Caco-2
13) Confidence 0.24 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
To the contrary, after ischemia-reperfusion injury, the localized expression of claudin-2 and claudin-4 observed in the non-treated control was lost and replaced with broader expression from crypts to villi with increased basolateral claudin-4 expression in epithelial cells.
Gene_expression (expression) of claudin-2 in epithelial cells associated with reperfusion injury and ischemia
14) Confidence 0.21 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1828083 Disease Relevance 0.70 Pain Relevance 0.16
Our results for the claudin-2 expression in the control intestine are congruent with those reported by Escaffit et al. [4], who demonstrated that claudin-2 was detected in both crypts and villus cells of the small intestine but was restricted to undifferentiated crypt cells in the colon.
Gene_expression (detected) of claudin-2 in villus
15) Confidence 0.21 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Claudin-2 showed a gradient of decreasing expression from crypts to villi, and no expression was observed on the tips of the villi even in extended focus images (Fig. 3B1, Fig. 4A1, A2).
Gene_expression (expression) of Claudin-2
16) Confidence 0.20 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.60 Pain Relevance 0.15
Contrary to occludin and claudin-1, the pore-forming TJ protein, claudin-2 [7], was only scarcely detectable in crypts of sham-operated animals, whereas rats from the AP group showed intense staining of claudin-2 both in crypt and surface epithelium (fig 3).
Gene_expression (detectable) of claudin-2 in surface epithelium associated with pancreatitis
17) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.62 Pain Relevance 0

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