INT205216

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 47
Total Number 49
Disease Relevance 9.47
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn4) plasma membrane (Cldn4) molecular_function (Cldn4)
Anatomy Link Frequency
epithelial cells 8
lateral surfaces 3
ileum 1
plasma 1
surface epithelium 1
Cldn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 1213 99.68 Very High Very High Very High
imagery 55 93.44 High High
cva 12 79.80 Quite High
bradykinin 3 51.44 Quite High
cytokine 104 50.32 Quite High
Inflammation 58 5.00 Very Low Very Low Very Low
anesthesia 46 5.00 Very Low Very Low Very Low
Inflammatory mediators 9 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 132 99.86 Very High Very High Very High
Cv Unclassified Under Development 1035 99.68 Very High Very High Very High
Reperfusion Injury 903 99.68 Very High Very High Very High
Toxicity 30 94.72 High High
Disseminated Intravascular Coagulation 86 89.24 High High
Cv General 4 Under Development 178 85.04 High High
Cv General 3 Under Development 9 79.80 Quite High
Necrosis 46 74.56 Quite High
Edema 27 72.20 Quite High
Enteropathy 43 64.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the changes in claudin-4 expression were significantly different from those in other tight-junction proteins, morphometric analysis of claudin-4 expression was performed.
Gene_expression (expression) of claudin-4
1) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Claudin-4 expression remained confined to the crypt, and its fluorescence intensity appeared stronger than that in the control (Fig. 5B).
Gene_expression (expression) of Claudin-4
2) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.16 Pain Relevance 0.04
For morphometric analysis of claudin-4 expression, a single optical plane was selected and four images of villi and four images of crypts were obtained from each section.
Gene_expression (expression) of claudin-4
3) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0.03
Immunohistochemistry using control sections of rat ileum demonstrated the expression of claudin-1, claudin-2, claudin-3, claudin-4, claudin-5, ZO-1, and occludin.
Gene_expression (expression) of claudin-4 in ileum
4) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.67 Pain Relevance 0.15
Claudin-4 expression was observed not only at the apical but also at the lateral surfaces of the cell (Fig. 5L).
Gene_expression (expression) of Claudin-4 in lateral surfaces
5) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.15 Pain Relevance 0.04
The number of positive pixels per cell was increased at 6 hr post-reperfusion and kept at the increased level at 24 hr post-reperfusion, demonstrating that the area with claudin-4 expression in the cell was increased during the recovery of epithelium.
Gene_expression (expression) of claudin-4 in epithelium
6) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Claudin-4 expression in the crypts was junctional and predominantly limited to the apical side of the cell-cell contact; basolateral expression was very weak (Fig. 5K).
Gene_expression (expression) of Claudin-4
7) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.18 Pain Relevance 0.04
The increase of the total gray density value of claudin-4 fluorescence per cell indicates that claudin-4 expression level was increased time-dependently during the recovery of epithelium.
Gene_expression (expression) of claudin-4 in epithelium
8) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Regarding the different patterns of changes of claudin-4 expression in the crypts and in the villi, we conjecture that the cells that survived the ischemia-reperfusion injury in the crypts were converted to overexpression of claudin-4 and migrated upwards to cover the apical surface.
Gene_expression (overexpression) of claudin-4 associated with reperfusion injury and ischemia
9) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.45 Pain Relevance 0.11
Our study suggests that claudin-4 overexpression plays an important role in cell migration which is essential at the early stages of epithelial recovery.
Gene_expression (overexpression) of claudin-4
10) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.13 Pain Relevance 0.03
The data for morphometric analysis of claudin-4 expression in the crypts were expressed as both the total grayscale value of claudin-4 fluorescence per area of crypt, and the number of claudin-4-positive pixels per area of crypt because it was not possible to collect the image of the crypts without cell overlapping and it was very difficult to count the number of cells per crypt.
Gene_expression (expression) of claudin-4
11) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Overexpression of claudin-4 was observed in rapidly migrating epithelial cells at the early stages of recovery, whereas at 48 hr post-reperfusion, when the structure of the villi and cell migration had returned to normal, overexpression was no longer observed.
Gene_expression (Overexpression) of claudin-4 in epithelial cells
12) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.12 Pain Relevance 0.03
The villous epithelium would then be reconstructed when these cells with strong claudin-4 expression reach the apical surface, which would result in increased claudin-4 expression in the villous epithelium.
Gene_expression (expression) of claudin-4 in epithelium
13) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.45 Pain Relevance 0.11
The data for morphometric analysis of claudin-4 expression in the villi were expressed as both the total grayscale value of claudin-4 fluorescence per cell and the number of claudin-4-positive pixels per cell.
Gene_expression (expression) of claudin-4
14) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Compared with the control samples, the fluorescence intensity of claudin-4 expression appeared increased at both villi and crypts and the expression was not localized to the tips of the villi but was extensively distributed on the villous epithelia (Fig. 3D3, Fig. 5C, 5H, 5M).
Gene_expression (expression) of claudin-4
15) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.12 Pain Relevance 0.03
In particular, the preferential expression of claudin-4 at the apical surface of the cell-cell contact in the crypt was expanded to apico-lateral expression at from 1 hr to 6 hr post-reperfusion.
Gene_expression (expression) of claudin-4 in lateral
16) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.28 Pain Relevance 0.07
Four separated crypts which were sliced as cross-sections and situated just above the muscularis mucosae were manually enclosed to measure the claudin-4 expression.
Gene_expression (expression) of claudin-4
17) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
At the tips of villi, the expression of claudin-4 was distributed at lateral surfaces (Fig. 5F).
Gene_expression (expression) of claudin-4 in lateral surfaces
18) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.18 Pain Relevance 0.05
Values for FITC-dextran-4 kDa concentration in plasma, grayscale value, and positive pixels in morphometric analysis of claudin-4 expression were calculated as mean±SD, and significant differences were defined using Scheffé’s test.
Gene_expression (expression) of claudin-4 in plasma
19) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.07 Pain Relevance 0
In addition, we found that the restricted expression of claudin-4 at the tips of the villi and at the extreme basal part of the crypt observed in the control were lost and replaced by broad expression over the entire surface epithelium by 24 hr post-reperfusion.
Gene_expression (expression) of claudin-4 in surface epithelium
20) Confidence 0.53 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.18 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox