INT205217

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.22
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn4) plasma membrane (Cldn4) molecular_function (Cldn4)
Anatomy Link Frequency
surface epithelium 4
epithelial cells 2
Cldn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 8 93.44 High High
ischemia 224 89.28 High High
cytokine 16 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 168 90.04 High High
Disseminated Intravascular Coagulation 16 89.72 High High
Cv Unclassified Under Development 192 89.28 High High
Body Weight 8 50.20 Quite High
Cv General 4 Under Development 32 17.56 Low Low
Enteropathy 8 5.00 Very Low Very Low Very Low
Necrosis 8 5.00 Very Low Very Low Very Low
Sepsis 8 5.00 Very Low Very Low Very Low
Injury 8 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we found that the restricted expression of claudin-4 at the tips of the villi and at the extreme basal part of the crypt observed in the control were lost and replaced by broad expression over the entire surface epithelium by 24 hr post-reperfusion.
Negative_regulation (lost) of Gene_expression (expression) of claudin-4 in surface epithelium
1) Confidence 0.40 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.23 Pain Relevance 0.07
In addition, we found that the restricted expression of claudin-4 at the tips of the villi and at the extreme basal part of the crypt observed in the control were lost and replaced by broad expression over the entire surface epithelium by 24 hr post-reperfusion.
Negative_regulation (replaced) of Gene_expression (expression) of claudin-4 in surface epithelium
2) Confidence 0.40 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.28 Pain Relevance 0.07
Claudin-4 expression in the crypts was junctional and predominantly limited to the apical side of the cell-cell contact; basolateral expression was very weak (Fig. 5K).
Negative_regulation (limited) of Gene_expression (expression) of Claudin-4
3) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.18 Pain Relevance 0.04
Morphometric analysis of claudin-4 expression
Negative_regulation (analysis) of Gene_expression (expression) of claudin-4
4) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.22 Pain Relevance 0.05
These results showed that claudin-4 expression level and area of expression in each crypt were the highest at 1 hr post-reperfusion and then decreased gradually, although they remained higher than in the control sample, during the recovery period.


Negative_regulation (decreased) of Gene_expression (expression) of claudin-4
5) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.15 Pain Relevance 0.04
These results showed that claudin-4 expression level and area of expression in each crypt were the highest at 1 hr post-reperfusion and then decreased gradually, although they remained higher than in the control sample, during the recovery period.


Negative_regulation (decreased) of Gene_expression (expression) of claudin-4
6) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.15 Pain Relevance 0.04
Morphometric analysis of claudin-4 expression
Negative_regulation (analysis) of Gene_expression (expression) of claudin-4
7) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Nine to thirteen epithelial cells, which were aligned but not overlapping each other, were manually enclosed to measure the claudin-4 expression.
Negative_regulation (measure) of Gene_expression (expression) of claudin-4 in epithelial cells
8) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0

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