INT205218

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.71
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
brain 1
epithelial cells 1
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 54 96.52 Very High Very High Very High
ischemia 46 65.80 Quite High
anesthesia 6 26.96 Quite Low
isoflurane 3 17.92 Low Low
imagery 9 14.00 Low Low
Glutamate 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Retinopathy 10 94.44 High High
Diabetes Mellitus 180 92.76 High High
Pancreatitis 80 88.96 High High
Injury 30 68.12 Quite High
Reperfusion Injury 28 66.56 Quite High
Cv Unclassified Under Development 32 65.80 Quite High
Brain Hemorrhage 40 52.00 Quite High
Peripheral Arterial Disease 8 45.84 Quite Low
Coronary Artery Disease 6 44.56 Quite Low
Pathologic Neovascularization 2 38.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homogenates were immunoblotted with occludin and claudin-5 (Zymed Laboratories, Carlsbad, CA), collagen IV (Abcam, Cambridge, MA), MMP-2, and MMP-9 (Calbiochem, Gibbstown, NJ) antibodies, respectively.
Localization (immunoblotted) of occludin associated with metalloproteinase
1) Confidence 0.46 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.05 Pain Relevance 0.16
Since tight junction proteins such as occludin and claudin-5 have essential roles in regulating BBB stability (36), we evaluated abundance of occludin, claudin-5, and collagen IV in the isolated micro- and macrovascular vessels from the brain.
Localization (abundance) of occludin in brain
2) Confidence 0.46 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.79 Pain Relevance 0.13
In sham-operated animals, occludin was localized in the cytoplasm of epithelial cells and along the basolateral membrane with an enrichment of occludin at the apical surface (fig 3).
Localization (localized) of occludin in epithelial cells
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.74 Pain Relevance 0
At 24 hr post-reperfusion, villi had recovered and the reticular pattern of distribution of ZO-1, occludin and claudin-1, -3, and -5 expression had also reverted to resemble that in the non-treated, control samples (Fig. 3A4, C4, E4–G4).
Localization (distribution) of occludin
4) Confidence 0.12 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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