INT205221

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn2) plasma membrane (Cldn2)
Anatomy Link Frequency
epithelial cells 2
Cldn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 56 99.30 Very High Very High Very High
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 42 99.68 Very High Very High Very High
Cv Unclassified Under Development 48 99.30 Very High Very High Very High
Cv General 4 Under Development 8 75.20 Quite High
Enteropathy 2 64.96 Quite High
Disseminated Intravascular Coagulation 4 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Sepsis 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To the contrary, after ischemia-reperfusion injury, the localized expression of claudin-2 and claudin-4 observed in the non-treated control was lost and replaced with broader expression from crypts to villi with increased basolateral claudin-4 expression in epithelial cells.
Negative_regulation (lost) of Gene_expression (expression) of claudin-2 in epithelial cells associated with reperfusion injury and ischemia
1) Confidence 0.15 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1828083 Disease Relevance 0.70 Pain Relevance 0.16
The decremental gradient of claudin-2 similar to that noted in the control sample was observed at 48 hr post-reperfusion, but claudin-2 expression still remained at the tips of the villi (Fig. 4E1, E2).
Negative_regulation (remained) of Gene_expression (expression) of claudin-2
2) Confidence 0.13 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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