INT205266

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.45
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Plec) plasma membrane (Plec) cytoskeleton (Plec)
cytoplasm (Plec)
Anatomy Link Frequency
nucleus 4
Plec (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 48 99.40 Very High Very High Very High
opioid receptor 30 99.22 Very High Very High Very High
Opioid 78 98.48 Very High Very High Very High
Morphine 18 97.52 Very High Very High Very High
MU agonist 9 95.28 Very High Very High Very High
Dynorphin 330 71.84 Quite High
imagery 201 50.00 Quite Low
ischemia 18 5.00 Very Low Very Low Very Low
Endogenous opioid 15 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 297 97.40 Very High Very High Very High
Stress 69 95.88 Very High Very High Very High
Cancer 156 56.80 Quite High
Metaplasia 18 55.56 Quite High
Sprains And Strains 72 55.44 Quite High
Pancreatic Cancer 63 5.00 Very Low Very Low Very Low
Infection 27 5.00 Very Low Very Low Very Low
Disease 24 5.00 Very Low Very Low Very Low
Flushing 18 5.00 Very Low Very Low Very Low
Injury 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a control for plectin-1 expression, we used NIH-3T3 cells, which are known to have plectin-1 in the cytoplasm and nucleus but not on the cell surface [29].
Regulation (control) of Gene_expression (expression) of plectin-1 in nucleus
1) Confidence 0.57 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0.46 Pain Relevance 0
Normal mouse pancreatic ductal cells had low levels of plectin-1 expression, whereas normal human pancreatic ductal cells had plectin-1 expression in the cytoplasm and nucleus but not on the membrane (Figure 4D).
Regulation (levels) of Gene_expression (expression) of plectin-1 in nucleus
2) Confidence 0.42 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0.53 Pain Relevance 0
All fractions were analyzed for plectin-1 expression via Western blotting.


Spec (analyzed) Regulation (analyzed) of Spec (analyzed) Gene_expression (expression) of plectin-1
3) Confidence 0.42 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0.15 Pain Relevance 0
Figure 2A outlines the critical pathways within the QS system that are involved in the regulation of PCN production.
Regulation (regulation) of Gene_expression (production) of PCN
4) Confidence 0.01 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0 Pain Relevance 0.50
An inhibitory effect of U-50,488 on PCN production was found in the complemented ?
Regulation (effect) of Gene_expression (production) of PCN
5) Confidence 0.01 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0 Pain Relevance 0.26
-opioid receptor agonists, and examined bacteria for a change in color and PCN production.
Spec (examined) Regulation (change) of Gene_expression (production) of PCN associated with agonist and opioid receptor
6) Confidence 0.01 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0.31 Pain Relevance 0.98

General Comments

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