INT205269

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.78
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Plec) plasma membrane (Plec) cytoskeleton (Plec)
cytoplasm (Plec)
Anatomy Link Frequency
3C11 1
Plec (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 3 100.00 Very High Very High Very High
Morphine 6 99.82 Very High Very High Very High
Dopamine 83 95.64 Very High Very High Very High
agonist 25 95.20 Very High Very High Very High
Bile 39 93.36 High High
Opioid 26 90.44 High High
MU agonist 3 82.08 Quite High
midbrain 20 74.76 Quite High
Inflammation 31 70.52 Quite High
opioid receptor 10 70.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 32 99.00 Very High Very High Very High
Adenocarcinoma 99 98.60 Very High Very High Very High
Repression 12 98.60 Very High Very High Very High
Hepatotoxicity 2 95.76 Very High Very High Very High
Infection 53 85.20 High High
Coronavirus Infection 3 83.32 Quite High
Severe Acute Respiratory Syndrome 7 82.44 Quite High
Disease Progression 4 72.80 Quite High
INFLAMMATION 26 70.52 Quite High
Stress 28 67.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that plectin-1 levels are low in normal pancreatic ductal cells, but its expression is upregulated in PanINs and remains elevated in PDAC.
Positive_regulation (upregulated) of plectin-1 associated with adenocarcinoma
1) Confidence 0.43 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0.47 Pain Relevance 0.09
We believe that induction of iBALT in response to treatment with PCN represents a promising strategy for pulmonary immunoprophylaxis.
Positive_regulation (induction) of PCN
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.68 Pain Relevance 0.10
For experiments in which dorsomorphin treatment was begun at the time of EB formation, EBs were generated by the aforementioned methods in the presence of dorsomorphin or DMSO.
Positive_regulation (generated) of EBs
3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483414 Disease Relevance 0 Pain Relevance 0
Targeted disruption of SXR abolishes the induction of CYP3A genes in response to prototypic inducers such as dexamethasone or PCN.
Positive_regulation (response) of PCN associated with targeted disruption and dexamethasone
4) Confidence 0.03 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.40 Pain Relevance 0.21
Although exposure to morphine did not increase PCN to the same degree as with U-50,488 (?
Neg (not) Positive_regulation (increase) of PCN associated with morphine
5) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0.13 Pain Relevance 1.03
In contrast, EBs derived from pHUSH-IVSTetRopt2×-TetO2 (2×-TetO2, clone 3C11) maintained a similar level of Dox-dependent regulation as had been observed with the parental, non-differentiated ES cells (additional file 3).
Positive_regulation (derived) of EBs in 3C11
6) Confidence 0.02 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.10 Pain Relevance 0
EBs derived from the BG02 line were tested with all five factors, and showed overall poor survival.
Positive_regulation (derived) of EBs
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.12
Total RNA samples were isolated in Trizol (Invitrogen) followed by purification over a Qiagen RNeasy column (Qiagen) from undifferentiated hESCs, day 12 EBs, hESC-ECs (after CD31/CD144 sort), and HUVECs.
Positive_regulation (after) of EBs
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0

General Comments

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