INT205272

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 1.50
Pain Relevance 4.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Plec) plasma membrane (Plec) cytoskeleton (Plec)
cytoplasm (Plec)
Anatomy Link Frequency
poly 4
nucleus 2
Plec (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 182 100.00 Very High Very High Very High
agonist 112 99.86 Very High Very High Very High
Endogenous opioid 35 98.00 Very High Very High Very High
Dynorphin 770 96.00 Very High Very High Very High
MU agonist 21 94.80 High High
Morphine 42 87.52 High High
opioid receptor 70 83.04 Quite High
Dopamine 166 76.24 Quite High
imagery 90 50.00 Quite Low
ischemia 45 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 99 94.32 High High
Stress 163 80.48 Quite High
Sprains And Strains 168 78.40 Quite High
Infection 64 65.88 Quite High
Cancer 60 53.72 Quite High
Metaplasia 6 52.48 Quite High
Targeted Disruption 12 52.36 Quite High
Neurodegenerative Disease 14 12.84 Low Low
Flushing 42 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Normal mouse pancreatic ductal cells had low levels of plectin-1 expression, whereas normal human pancreatic ductal cells had plectin-1 expression in the cytoplasm and nucleus but not on the membrane (Figure 4D).
Neg (not) Positive_regulation (had) of Gene_expression (expression) of plectin-1 in nucleus
1) Confidence 0.43 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0.46 Pain Relevance 0
The EBs were transferred to uncoated Petri dishes and suspended in differentiation media for two days (Day 2–Day 4).
Positive_regulation (transferred) of Gene_expression (transferred) of EBs
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483414 Disease Relevance 0 Pain Relevance 0
To promote cardiac differentiation, 9-day old EBs were transferred to 10 cm dishes coated with 0.1% gelatin and grown in media consisting of DMEM supplemented with 20% FBS and 2 mmol/L L-glutamine.
Positive_regulation (transferred) of Gene_expression (transferred) of EBs
3) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.12 Pain Relevance 0
RhlI, PCN production was increased in response to C4-HSL, possibly as a result of the absence 3-oxo-C12-HS.
Positive_regulation (increased) of Gene_expression (production) of PCN
4) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0 Pain Relevance 0.32
U-50,488 induced PCN production at earlier cell density without affecting bacterial growth, suggesting a regulatory shift in the quorum sensing circuitry of P. aeruginosa (Figure 1I).


Positive_regulation (induced) of Gene_expression (production) of PCN
5) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0 Pain Relevance 0.79
Having established that opioid-induced PCN production in P. aeruginosa is specific to ?
Positive_regulation (-) of Gene_expression (production) of PCN associated with opioid
6) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0.22 Pain Relevance 0.56
Having established that opioid-induced PCN production in P. aeruginosa is specific to ?
Positive_regulation (induced) of Gene_expression (production) of PCN associated with opioid
7) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0.22 Pain Relevance 0.56
-agonists could induce PCN production in P. aeruginosa.
Positive_regulation (induce) of Gene_expression (production) of PCN associated with agonist
8) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0.26 Pain Relevance 0.62
-opioid U-50,488 induced an intensely bright green color in P. aeruginosa PAO1 that correlated to an increase in PCN production in a dose-dependent manner (Figure 1B).
Positive_regulation (increase) of Gene_expression (production) of PCN associated with opioid
9) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0.21 Pain Relevance 1.13
-opioid mediated activation of PCN production requires an intact QS system, P. aeruginosa PAO1 mutants defective in key transcriptional regulators RhlR, LasR, GacA, and MvfR, as well as the autoinducer synthetases RhlI and LasI, were exposed to U-50,488 at concentrations of up to 1 mM.
Positive_regulation (requires) of Gene_expression (production) of PCN associated with opioid
10) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0 Pain Relevance 0.44
After two-four days, resultant EBs were transferred to poly-L ornithine/laminin coated dishes and were allowed to differentiate in the presence of heparin and selected molecules.
Positive_regulation (transferred) of Gene_expression (transferred) of EBs in poly
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.07
After 2–4 days, the EBs were transferred to plates precoated with poly-L-ornithine (100 µg/ml, Sigma), and then laminin (20 µg/ml, Invitrogen) and cultured in hESC medium in the presence of heparin (100 µg/ml, Sigma) and the various factors.
Positive_regulation (transferred) of Gene_expression (transferred) of EBs in poly
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0

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