INT205275

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.93
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Plec) plasma membrane (Plec) cytoskeleton (Plec)
cytoplasm (Plec)
Plec (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 110 98.28 Very High Very High Very High
Endogenous opioid 5 86.04 High High
agonist 16 83.20 Quite High
Opioid 26 77.04 Quite High
imagery 134 62.48 Quite High
isoflurane 5 44.64 Quite Low
fibrosis 2 24.96 Low Low
Inflammation 33 5.00 Very Low Very Low Very Low
opioid receptor 10 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Loss 32 98.76 Very High Very High Very High
Adenocarcinoma 198 98.68 Very High Very High Very High
Body Weight 9 97.28 Very High Very High Very High
Influenza Virus Infection 90 96.04 Very High Very High Very High
Infection 129 91.32 High High
Sprains And Strains 33 90.00 High High
Targeted Disruption 7 70.08 Quite High
Shock 15 52.20 Quite High
Cancer 103 29.68 Quite Low
Metaplasia 12 28.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Normal animals had scattered plectin-1 staining, whereas in PanINs and PDAC, plectin-1 was expressed in the lesions but not in the surrounding tissue (Figure 4E).
Regulation (scattered) of plectin-1 associated with adenocarcinoma
1) Confidence 0.42 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0.48 Pain Relevance 0.06
To produce plectin-1 targeted or control nanoparticles, succinimidyl iodoacetic acid was reacted with CLIO-Cy5.5 for 15 min, purified by size exclusion chromatography, then reacted with peptidyl-cysteine for 1 h.
Regulation (targeted) of plectin-1
2) Confidence 0.25 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0 Pain Relevance 0.03
Role of iBALT in PCN-enhanced protection
Regulation (Role) of PCN
3) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.67 Pain Relevance 0
However, protection against weight loss was not as enduring (Figure 8B), further suggesting that the PCN-induced mechanisms responsible for accelerated viral clearance may be distinct from those responsible for decreased weight loss.
Regulation (responsible) of PCN-induced associated with weight loss
4) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.60 Pain Relevance 0
Thus, the PCN-induced mechanisms responsible for accelerated viral clearance may be distinct from those responsible for decreased weight loss.
Regulation (responsible) of PCN-induced associated with weight loss
5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.97 Pain Relevance 0
We next determined if dynorphin increased the expression of mvfR, pqsABCDE, and phzA1-G1, key components involved in PCN regulation.
Regulation (regulation) of PCN associated with dynorphin
6) Confidence 0.01 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1828698 Disease Relevance 0.20 Pain Relevance 0.71

General Comments

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