INT205441

Context Info Confidence 0.51 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.04

unfolded protein binding (CRYAB) protein folding (CRYAB) nucleus (CRYAB) cytoplasm (CRYAB)

Anatomy Link Frequency osteoblasts 1 CRYAB (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 2 72.76 dexamethasone 4 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Osteoporosis 24 50.00 Spinal Cord Diseases 2 34.28 Adhesions 6 11.44 Shock 2 6.56 Obesity 6 5.00 Reprotox - General 1 6 5.00 Calcification 2 5.00 Infarction 2 5.00 Communicable Diseases 2 5.00 Toxicity 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further studies are necessary to quantify the expression of ID4, SORT-1 and CRYAB in primary human osteoblasts and other cell types and to identify the role of these genes in osteogenesis.

Gene_expression (expression) of CRYAB in osteoblasts

1) Confidence 0.51 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0.04

Additionally, novel candidate genes could be found which are not known to play a role during osteogenic differentiation: ID4 (inhibitor of DNA-binding), CRYAB (crystalline-?

Gene_expression (crystalline) of CRYAB

2) Confidence 0.39 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0

General Comments

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