INT205470

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.53
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (GATA3) anatomical structure formation involved in morphogenesis (GATA3) DNA binding (GATA3)
signal transduction (GATA3) nucleolus (GATA3) nucleus (GATA3)
Anatomy Link Frequency
red blood cells 1
GATA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1 100.00 Very High Very High Very High
cytokine 56 92.40 High High
Inflammation 102 84.08 Quite High
tolerance 13 29.28 Quite Low
depression 2 16.56 Low Low
Neuropathic pain 2 15.60 Low Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 193 96.84 Very High Very High Very High
Malaria 64 86.28 High High
Fever 32 84.68 Quite High
Breast Cancer 48 84.48 Quite High
INFLAMMATION 102 84.08 Quite High
Carcinoma 2 68.84 Quite High
Apoptosis 7 67.28 Quite High
Autoimmune Disease 12 66.28 Quite High
Infection 13 50.00 Quite Low
Anaemia 18 44.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulated ESR1, GATA3, ERBB4, TFF1 and TFF3 gene expression was associated with ER+ ERBB2-amplified tumors.
Positive_regulation (Upregulated) of GATA3 associated with cancer
1) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.94 Pain Relevance 0
GATA3, ESR1, TFF1, TFF3 and ERBB4 were upregulated, whereas IGF2R, GATA6, EGFR and TGFA were downregulated in ER+ ERBB2-amplified tumors.
Positive_regulation (upregulated) of GATA3 associated with cancer
2) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.81 Pain Relevance 0
doesn't blunt IL-4 mediated induction of GATA-3 (Fig 3B), yet TGF-?
Positive_regulation (induction) of GATA-3
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.31 Pain Relevance 0.33
Functional candidates include genes encoding a platelet-type phosphofructokinase (PFKP) also expressed in red blood cells, an inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2/PFKFB3), the alpha chain of the interleukin-15 receptor (IL15RA), the alpha chain of the interleukin 2 receptor (IL2RA), protein kinase C theta (PRKCQ), the GATA-binding protein 3 (GATA3), and a gene similar to that of the interleukin 9 receptor precursor (LOC439945).
Positive_regulation (inducible) of GATA-binding protein 3 in red blood cells associated with kinase c
4) Confidence 0.08 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1829404 Disease Relevance 0.33 Pain Relevance 0.05
These transcription factors include T-bet for TH1 cells, and GATA-3 for TH2 cells [62].
Positive_regulation (include) of GATA-3
5) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.13 Pain Relevance 0.22

General Comments

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