INT205494

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.20
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 92 100.00 Very High Very High Very High
COX-2 inhibitor 10 99.92 Very High Very High Very High
Inflammatory mediators 16 65.08 Quite High
depression 1 50.80 Quite High
cINOD 29 43.84 Quite Low
Inflammatory stimuli 4 26.48 Quite Low
Arthritis 2 9.32 Low Low
Crohn's disease 1 6.20 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 125 100.00 Very High Very High Very High
Cancer 9 97.54 Very High Very High Very High
Chronic Disease 2 96.68 Very High Very High Very High
Disease 19 64.08 Quite High
Depression 1 50.80 Quite High
Suicidal Behaviour 1 33.08 Quite Low
Arthritis 2 9.32 Low Low
Inflammatory Bowel Disease 3 5.40 Low Low
Pain 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simulations on widely used anti-inflammatory inhibitors, including 5-LOX inhibitor, COX-2 inhibitor, and a combination of the two, were performed (Figure 3).
Negative_regulation (inhibitors) of Negative_regulation (inhibitor) of 5-LOX associated with inflammation and cox-2 inhibitor
1) Confidence 0.32 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1829479 Disease Relevance 0.32 Pain Relevance 0.26
We have been studying the effects of several dietary polyphenol compounds (including resveratrol, genistein, catechin, and indole-3-carbinol) on chronic diseases in humans, such as inflammation and cancer.6-9 The potential molecular mechanisms of their anti-inflammatory activities have also been suggested to include, but not limited to, the inhibition of enzymes related to inflammation, such as cyclooxygenase and lipoxygenase, and many others including PPAR, NOS, NF-?
Negative_regulation (limited) of Negative_regulation (inhibition) of lipoxygenase associated with inflammation, cancer and chronic disease
2) Confidence 0.03 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.88 Pain Relevance 0.28

General Comments

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