INT205497

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 15.91
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NOLC1) mitosis (NOLC1) nucleolus (NOLC1)
nucleus (NOLC1) cell cycle (NOLC1) DNA binding (NOLC1)
Anatomy Link Frequency
blood 1
brain 1
NOLC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 20 99.82 Very High Very High Very High
qutenza 260 98.08 Very High Very High Very High
glial activation 6 88.24 High High
Inflammatory response 6 85.60 High High
Opioid 7 85.32 High High
cytokine 33 82.00 Quite High
Neurobehavioral 21 65.48 Quite High
addiction 9 53.88 Quite High
Central nervous system 9 22.56 Low Low
drug abuse 15 8.00 Low Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 1337 100.00 Very High Very High Very High
Infection 429 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 270 99.90 Very High Very High Very High
Hepatitis 45 99.38 Very High Very High Very High
Cancer 124 98.64 Very High Very High Very High
Retinoblastoma 1 98.42 Very High Very High Very High
Liver Disease 9 97.40 Very High Very High Very High
Disease 34 96.68 Very High Very High Very High
Carcinoma 10 94.28 High High
Cirrhosis 10 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant association between age and HCV (p?
HCV Binding (association) of associated with hepatitis c virus infection
1) Confidence 0.35 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.17 Pain Relevance 0
Of note, we did not find a direct association between HCV and the reporting of specific practices while in jail, only the global indicator of past incarceration.
HCV Neg (not) Binding (association) of associated with hepatitis c virus infection
2) Confidence 0.35 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.16 Pain Relevance 0.08
We also found that history of tattooing, a practice also common to incarcerated populations, was an independent risk factor for HCV infection.18,27–29 In the abovementioned study of prisoners in Zanjan, tattooing was also associated with HCV positivity among prisoners.18
HCV Binding (associated) of associated with hepatitis c virus infection and infection
3) Confidence 0.26 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.08 Pain Relevance 0.09
Factors independently associated with HCV infection included history of incarceration (adjusted OR 4.35, 95% CI 1.88–10.08), age of first injection ?
HCV Binding (associated) of associated with hepatitis c virus infection and infection
4) Confidence 0.26 Published 2009 Journal J Urban Health Section Abstract Doc Link PMC2791818 Disease Relevance 1.11 Pain Relevance 0
Multiple logistic regression analysis was used to determine associations with HCV infection.
HCV Binding (associations) of associated with hepatitis c virus infection and infection
5) Confidence 0.26 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 0.63 Pain Relevance 0.03
HCV infection is recognized as the most common blood-borne infection in injection drug users (IDU).
HCV Binding (recognized) of in blood associated with hepatitis c virus infection and infection
6) Confidence 0.26 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 1.31 Pain Relevance 0
Variables associated with HCV in bivariate analysis at the p???
HCV Binding (associated) of associated with hepatitis c virus infection
7) Confidence 0.26 Published 2009 Journal J Urban Health Section Body Doc Link PMC2791818 Disease Relevance 0.63 Pain Relevance 0.03
In contrast, very low levels of p130 were bound to these promoters in proliferating cells (Fig. 6, left panel, last lane from left).
p130 Binding (bound) of
8) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.19 Pain Relevance 0.39
E2Fs 1–3 can bind to the Rb protein, but E2Fs 4 and 5 preferentially bind to p107 and p130 proteins [24], [25], [26], [29], [30].
p130 Binding (bind) of
9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0 Pain Relevance 0
The most significant cellular targets of E7 are the retinoblastoma (Rb) tumor suppressor protein and its functionally related proteins, p107 and p130, especially in their hypophosphorylated active forms, which are able to inhibit cell cycle progression by binding and repressing the activity of E2F cellular transcription factors [42].
p130 Binding (binding) of associated with cancer and retinoblastoma
10) Confidence 0.03 Published 2008 Journal Infect Agent Cancer Section Body Doc Link PMC2628336 Disease Relevance 1.04 Pain Relevance 0
Future studies are required to delineate the precise mechanisms by which HIV and HCV proteins interact and amplify neuropathogenesis, thereby permitting the development of potential management and therapeutic strategies.


HCV Binding (interact) of associated with acquired immune deficiency syndrome or hiv infection and hepatitis c virus infection
11) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.52 Pain Relevance 0.09
This possibility might highlight the importance of interactions between HCV and HIV and warrants further investigation.
HCV Binding (interactions) of associated with acquired immune deficiency syndrome or hiv infection and hepatitis c virus infection
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.80 Pain Relevance 0.07
Although HCV tropism is principally recognized in human liver cells, extrahepatic replication has been reported in PBMC [48], myocardium [49], [50] and brain cells [10], [18] by detecting HCV negative-strand RNA.
HCV Binding (recognized) of in brain associated with hepatitis c virus infection
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.78 Pain Relevance 0.04
Given the limited knowledge about HCV on the part of these NIDUs and IDUs and their moderate recognition of their need for HCV education, it is of considerable concern that less than two thirds of them obtained such education in any form at their drug treatment programs.
HCV Binding (recognition) of associated with hepatitis c virus infection
14) Confidence 0.00 Published 2007 Journal BMC Health Serv Res Section Body Doc Link PMC1831471 Disease Relevance 0.89 Pain Relevance 0
These items had to do with HCV transmission; the duration of HCV treatment; distinguishing the various types of hepatitis infections, methadone and its interaction with HCV treatment; the absence of an HCV vaccine; the possibility of spontaneous clearance of HCV infection; and the risk of contracting HCV relative to HIV.


HCV Binding (interaction) of associated with acquired immune deficiency syndrome or hiv infection, methadone, hepatitis c virus infection, infection and hepatitis
15) Confidence 0.00 Published 2007 Journal BMC Health Serv Res Section Body Doc Link PMC1831471 Disease Relevance 1.62 Pain Relevance 0.10

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