INT2055
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
These results support the hypothesis that LHRH neurons are regulated indirectly by opiatergic neurons. | |||||||||||||||
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There was no change in hypothalamic luteinizing hormone releasing hormone (LHRH) mRNA, pro-LHRH, or LHRH in any group at either age. | |||||||||||||||
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Injection of normal saline had no effect on GnRH concentration in pituitary portal blood in INT rats. | |||||||||||||||
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For each, we have attempted to determine how and where the regulatory input is manifest and, according to our working premise, we have attempted to identify factors which specifically regulate the LHRH pulse generator. | |||||||||||||||
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The endogenous opioid peptides, for example, primarily regulate LHRH pulse amplitude (Karahalios and Levine, 1988), a finding that is consistent with the idea that these peptides exert direct postsynaptic or presynaptic inhibition (Drouva et al., 1981). | |||||||||||||||
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We have analyzed the mechanisms by which several known regulators of the LHRH release process may exert their effects. | |||||||||||||||
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The LHRH neurosecretory system thus appears to be regulated at many levels, and by a variety of neural and endocrine factors. | |||||||||||||||
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Specific lesions of different brain structures known to contain or to be coursed by LHRH neurons have been carried out in intact cycling female rats in order to investigate the role played by central LHRH and neuronal systems in the regulation of ovarian and hypophyseal LHRH receptor (LHRH-R) levels, using the stable LHRH analog [D-Ser (TBU)6] Des-Gly10, LHRH ethylamide, buserelin. | |||||||||||||||
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Specific lesions of different brain structures known to contain or to be coursed by LHRH neurons have been carried out in intact cycling female rats in order to investigate the role played by central LHRH and neuronal systems in the regulation of ovarian and hypophyseal LHRH receptor (LHRH-R) levels, using the stable LHRH analog [D-Ser (TBU)6] Des-Gly10, LHRH ethylamide, buserelin. | |||||||||||||||
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Finally, serotonergic, dopaminergic, opioid, and noradrenergic regulation of GnRH varies with increasing age, and the sexual organization of the hypothalamus by testosterone or estrogens is a determinant in such regulation. | |||||||||||||||
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Exogenous and endogenous opioid-induced enhancements of naloxone's effects on serum luteinizing hormone levels in the male rat. | |||||||||||||||
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Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats. | |||||||||||||||
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GnRH neurone recruitment and activity is regulated by a balance between stimulation, suppression and permissiveness controlled by noradrenaline, neuropeptide Y and serotonin from the brain stem, impact from glutamate in the medial preoptic area and neuropeptide Y in the arcuate nucleus, in opposition to the restraining influences of gamma-aminobenzoic acid within the medial preoptic area and opioids from the arcuate nucleus. | |||||||||||||||
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NMDA rapidly induces LH release but whether this drug directly affects the activity of LHRH neurons is not known. | |||||||||||||||
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These observations showed that galaninergic neurons but not GnRH neurons of the preoptic area might be directly regulated by endogenous opioid peptides. | |||||||||||||||
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Opioids play an important role in the regulation of lutenizing hormone releasing hormone (LHRH). | |||||||||||||||
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Opioids play an important role in the regulation of lutenizing hormone releasing hormone (LHRH). | |||||||||||||||
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Because Fos is thought to be induced in neurons that are activated, we examined whether luteinizing hormone-releasing hormone (LHRH) neurons expressed Fos protein when they were stimulated by an opioid receptor antagonist naloxone (NAL), expecting to identify LHRH neurons which are regulated by opioid neurons directly or indirectly. | |||||||||||||||
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These results show that LPS has a suprapituitary site(s) of action to suppress the activity of GnRH neurones in female rats, and suggest that LPS affects the opioid, as well as the excitatory amino acidergic regulation of GnRH neurones. | |||||||||||||||
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In order to investigate the role of opiates in the regulation of GnRH gene expression in the rat brain, we studied the effects of chronic administration of the opioid drug morphine and an opiate receptor antagonist naloxone on GnRH mRNA levels as measured by in situ hybridization. | |||||||||||||||
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General Comments
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