INT20550

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 4.29
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwa2) biological_process (Vwa2)
Anatomy Link Frequency
chondrocytes 2
cartilage 1
extracellular matrix 1
lungs 1
mononuclear cells 1
Vwa2 (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 4 98.94 Very High Very High Very High
rheumatoid arthritis 7 98.34 Very High Very High Very High
Inflammation 21 98.00 Very High Very High Very High
cINOD 12 95.12 Very High Very High Very High
Snapping jaw 9 94.60 High High
metalloproteinase 2 86.16 High High
fibrosis 66 75.00 Quite High
cytokine 4 75.00 Quite High
Potency 2 74.40 Quite High
Inflammatory marker 2 56.96 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 106 99.84 Very High Very High Very High
Osteoarthritis 4 99.56 Very High Very High Very High
Disease 16 99.48 Very High Very High Very High
Low Back Pain 4 98.94 Very High Very High Very High
Crystal Associated Disease 4 98.46 Very High Very High Very High
Rheumatoid Arthritis 7 98.34 Very High Very High Very High
INFLAMMATION 29 98.00 Very High Very High Very High
Cancer 16 96.84 Very High Very High Very High
Temporomandibular Joint Syndrome 9 94.60 High High
Targeted Disruption 13 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies with Apc(Min/+)/Mmp7(-/-) double-deficient mice demonstrated the reciprocal relationships of Mmp7 expression and the levels of these three collagens in vivo.
Gene_expression (levels) of collagens
1) Confidence 0.04 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.56 Pain Relevance 0.08
The results of this study demonstrated that sulindac was effective in increasing the expression of different collagens and decreasing the expression of Mmp7, effects that may contribute to altered tumor burden in cancer patients undergoing NSAIDs treatments.
Gene_expression (expression) of collagens associated with cancer and cinod
2) Confidence 0.03 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 18499699 Disease Relevance 0.67 Pain Relevance 0.10
In the treatment of lungs, SPARC siRNA reduced the disruption and inflammatory cells of the alveoli induced by bleomycin (Figure 4-2), which was accompanied with attenuated gene expression and protein content of collagens as compared to that without siRNA treatment (Figures 5B and 4-3).
Gene_expression (expression) of collagens in lungs associated with inflammation
3) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.78 Pain Relevance 0.35
SPARC is a matricellular protein, which, along with other extracellular matrix components including collagens, is commonly over-expressed in fibrotic diseases.
Gene_expression (expressed) of collagens in extracellular matrix associated with fibrosis and disease
4) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888211 Disease Relevance 0.49 Pain Relevance 0.07
This maintenance involves both the removal and re-synthesis of structural proteins such as collagens, elastins and proteoglycans.
Gene_expression (re-synthesis) of collagens
5) Confidence 0.02 Published 2001 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 11455120 Disease Relevance 0.72 Pain Relevance 0.83
Peripheral blood mononuclear cells from patients with rheumatoid arthritis, gout, ankylosing spondylitis and degenerative joint disease were cultured in the presence of native types I, II and III collagens and alpha chains from each of these types of collagen.
Gene_expression (presence) of collagens in mononuclear cells associated with spinal inflammation, rheumatoid arthritis, crystal associated disease and osteoarthritis
6) Confidence 0.01 Published 1980 Journal Am. J. Med. Section Abstract Doc Link 7386498 Disease Relevance 0.94 Pain Relevance 0.32
The ability of costal chondrocytes (CCs) to produce relevant extracellular matrix, including glycosaminoglycans (GAGs) and collagens, makes them an appealing cell source for fibrocartilage engineering.
Gene_expression (produce) of collagens in chondrocytes
7) Confidence 0.00 Published 2008 Journal Ann Biomed Eng Section Abstract Doc Link 18830818 Disease Relevance 0.07 Pain Relevance 0.07
We have shown that interleukin-1 (IL-1) suppresses expression of cartilage-specific types II and IX collagens by cultured human chondrocytes.
Gene_expression (expression) of collagens in chondrocytes
8) Confidence 0.00 Published 1990 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 2146129 Disease Relevance 0 Pain Relevance 0.09
In contrast, expression of types I and III collagens and fibronectin, matrix components produced by chondrocytes that have lost cartilage-specific phenotype, is increased by IL-1, particularly when IL-1-stimulated synthesis of PGE2 is blocked by a prostaglandin synthetase inhibitor.
Gene_expression (expression) of collagens in cartilage
9) Confidence 0.00 Published 1990 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 2146129 Disease Relevance 0.05 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox