INT20551

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Context Info
Confidence 0.55
First Reported 1990
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 31
Total Number 35
Disease Relevance 21.98
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) cytoplasm (COL2A1)
Anatomy Link Frequency
cleavage 4
chondrocytes 2
upper respiratory tract 1
colon 1
cartilages 1
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 23 99.76 Very High Very High Very High
Osteoarthritis 261 99.32 Very High Very High Very High
Earache 11 98.54 Very High Very High Very High
metalloproteinase 114 97.72 Very High Very High Very High
antagonist 13 93.88 High High
alcohol 12 90.88 High High
Inflammation 108 82.56 Quite High
rheumatoid arthritis 16 79.76 Quite High
cytokine 71 79.44 Quite High
cINOD 13 78.44 Quite High
Disease Link Frequency Relevance Heat
Otitis Media 808 100.00 Very High Very High Very High
Pneumonia 56 100.00 Very High Very High Very High
Aberrant Crypt Foci 3 100.00 Very High Very High Very High
Disease 165 99.92 Very High Very High Very High
Otitis 43 99.84 Very High Very High Very High
Pain 20 99.76 Very High Very High Very High
Colon Cancer 15 99.60 Very High Very High Very High
Infection 79 99.56 Very High Very High Very High
Osteoarthritis 341 99.32 Very High Very High Very High
Bacterial Meningitis 51 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, while the SOX9 dependency of COL2A1 expression has been unequivocally shown, it may not actually be a key regulator of COL2A1 promoter activity in human adult articular chondrocytes [82].
Negative_regulation (regulator) of COL2A1 in chondrocytes
1) Confidence 0.55 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.12 Pain Relevance 0
Pneumococcal AOM caused by serotypes contained in the vaccine was reduced by 57% (27).
Negative_regulation (reduced) of AOM associated with otitis media
2) Confidence 0.50 Published 2007 Journal Journal of Health, Population, and Nutrition Section Body Doc Link PMC2754010 Disease Relevance 1.33 Pain Relevance 0
One previous study evaluated OMT for prevention of AOM in otitis-prone children [7].
Negative_regulation (prevention) of AOM associated with otitis media and otitis
3) Confidence 0.48 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2573879 Disease Relevance 0.57 Pain Relevance 0.05
However, in most examined cartilages and as shown by the group analyses, significant downregulation of collagen cleavage was observed at 10 pg/ml PGE2 in these four individual patients (Figure 1e) and in a larger cohort of 13 other patients (Figure 1f).
Negative_regulation (downregulation) of collagen in cartilages
4) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.30 Pain Relevance 0.15
Thus, repeated application of PGE2 with each medium change may have been enough to decrease collagen cleavage.
Negative_regulation (decrease) of collagen in cleavage
5) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.52 Pain Relevance 0.28
The effect of added PGE2 and the interrelationships we observed in control cultures suggests an interesting dynamic in which PGE2 in the range 0 to 70 pg/ml released from OA specimens is associated with the suppression of collagen cleavage.
Negative_regulation (suppression) of collagen in cleavage associated with osteoarthritis
6) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.34 Pain Relevance 0.17
Downregulation of collagen cleavage was not accompanied by significant changes in GAG release in explants cultured in the presence of 10 pg/ml PGE2 (Figure 2).
Negative_regulation (Downregulation) of collagen in cleavage
7) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.48 Pain Relevance 0.27
An increase in PGE2 levels in OA articular cartilage explants was accompanied by a linear (correlation coefficient r = -0.507; P = 0.044) decrease in collagen cleavage.


Negative_regulation (decrease) of collagen in cleavage associated with osteoarthritis
8) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.57 Pain Relevance 0.29
Similarly, we described an episode of AOM as improved if: i) the ear discharge had resolved but bulging of the TM persisted in AOM with perforation, or ii) the bulging of the TM was reduced to mild in AOM without perforation.
Negative_regulation (reduced) of AOM in ear associated with otitis media
9) Confidence 0.37 Published 2005 Journal BMC Pediatr Section Body Doc Link PMC1177962 Disease Relevance 0.86 Pain Relevance 0
We set out to determine the efficacy of topical aqueous 2% lignocaine eardrops compared with a placebo (saline) for pain relief of AOM in children.
Negative_regulation (relief) of AOM associated with pain and otitis media
10) Confidence 0.37 Published 2008 Journal Arch. Dis. Child. Section Abstract Doc Link 18156478 Disease Relevance 0.72 Pain Relevance 0.27
OBJECTIVES: To determine the effectiveness of long-term antibiotics (for longer than six weeks) in preventing any AOM, AOM with perforation and CSOM.
Negative_regulation (preventing) of AOM
11) Confidence 0.37 Published 2006 Journal Cochrane Database Syst Rev Section Body Doc Link 17054203 Disease Relevance 0.10 Pain Relevance 0
OBJECTIVES: To determine the effectiveness of long-term antibiotics (for longer than six weeks) in preventing any AOM, AOM with perforation and CSOM.
Negative_regulation (preventing) of AOM
12) Confidence 0.37 Published 2006 Journal Cochrane Database Syst Rev Section Body Doc Link 17054203 Disease Relevance 0.10 Pain Relevance 0
The guideline also addresses the management of otalgia, choice of antibiotics after initial treatment failure, and methods for preventing AOM.
Negative_regulation (preventing) of AOM associated with otitis media and earache
13) Confidence 0.37 Published 2006 Journal Curr Allergy Asthma Rep Section Abstract Doc Link 16822388 Disease Relevance 0.99 Pain Relevance 0.14
Because most episodes of AOM follow upper respiratory tract infections, it is plausible that treatment of such infections with echinacea might decrease the risk of subsequent AOM.
Spec (might) Negative_regulation (decrease) of AOM in upper respiratory tract associated with common cold, otitis media and infection
14) Confidence 0.36 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2573879 Disease Relevance 1.64 Pain Relevance 0.15
This is the first randomized, placebo-controlled trial of Echinacea purpurea for the prevention of AOM.
Negative_regulation (prevention) of AOM associated with otitis media
15) Confidence 0.36 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2573879 Disease Relevance 0.70 Pain Relevance 0.03
Considering the importance of H. influenzae as a causative agent of AOM, a conjugate vaccine with efficacy against both H. influenzae and S. pneumoniae could potentially prevent most bacterial AOM among Colombian children.


Negative_regulation (prevent) of AOM associated with otitis media
16) Confidence 0.30 Published 2011 Journal BMC Infect Dis Section Body Doc Link PMC3023699 Disease Relevance 1.19 Pain Relevance 0
The estimated annual disease burden of AOM ranges between 8,200,000 and 12,900,000 cases among children less than five years of age in Latin America and the Caribbean [3], compared to that in US children [4] where the estimated number of AOM per year are 10,200,000.
Negative_regulation (number) of AOM associated with otitis media and disease
17) Confidence 0.30 Published 2011 Journal BMC Infect Dis Section Body Doc Link PMC3023699 Disease Relevance 1.53 Pain Relevance 0
Widespread immunization of children with pneumococcal conjugate vaccines might play a role in reducing AOM episodes.
Negative_regulation (reducing) of AOM associated with otitis media and immunization
18) Confidence 0.30 Published 2011 Journal BMC Infect Dis Section Body Doc Link PMC3023699 Disease Relevance 1.00 Pain Relevance 0
A slight reduction of the incidence of AOM of 6–8% was observed in the USA [7].


Negative_regulation (reduction) of AOM associated with otitis media
19) Confidence 0.30 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC1876255 Disease Relevance 1.09 Pain Relevance 0
Indomethacin (0.3-300 nM) or ketoprofen (2-2000 nM) produced a dose-dependent suppression of type II collagen synthesis associated with decreased levels of type II collagen mRNA in the absence of IL-1, while they potentiated the inhibitory effects of IL-1.
Negative_regulation (decreased) of type II collagen
20) Confidence 0.24 Published 1990 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 2146129 Disease Relevance 0.08 Pain Relevance 0.26

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