INT20552

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Context Info
Confidence 0.56
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 11.92
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) cytoplasm (COL2A1)
Anatomy Link Frequency
cleavage 10
chondrocyte 8
cartilage 8
articular 2
articular cartilage 2
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 874 99.84 Very High Very High Very High
antagonist 16 99.82 Very High Very High Very High
cytokine 134 98.92 Very High Very High Very High
metalloproteinase 188 98.24 Very High Very High Very High
Mechanotransduction 30 96.48 Very High Very High Very High
Inflammation 240 95.04 Very High Very High Very High
Inflammatory response 32 84.56 Quite High
cINOD 28 80.76 Quite High
Potency 2 70.16 Quite High
Arthritis 61 67.08 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 995 99.84 Very High Very High Very High
Hypertrophy 182 99.80 Very High Very High Very High
Aging 20 99.38 Very High Very High Very High
Osteophyte 12 98.92 Very High Very High Very High
Disease 143 96.08 Very High Very High Very High
INFLAMMATION 282 95.04 Very High Very High Very High
Leukemia 4 94.16 High High
Apoptosis 146 94.08 High High
Arthropathy 8 91.08 High High
Intervertebral Disk Degeneration 85 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It can inhibit collagen synthesis in growth plate chondrocytes [27], mediate MMP production in articular chondrocytes and cartilage [6,28], inhibit chondrocyte proliferation [29], promote IL-1?
Negative_regulation (inhibit) of Gene_expression (synthesis) of collagen in articular associated with metalloproteinase
1) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.94 Pain Relevance 0.28
Our experimental system containing added 10 pg/ml PGE2 produced chondroprotection on OA articular cartilage in that it downregulated collagen cleavage and the expression of genes associated with collagen cleavage, proinflammatory cytokines and hypertrophy.
Negative_regulation (downregulated) of Gene_expression (expression) of collagen in cleavage associated with hypertrophy, osteoarthritis and cytokine
2) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.62 Pain Relevance 0.19
Thus, repeated application of PGE2 with each medium change may have been enough to decrease collagen cleavage.
Negative_regulation (decrease) of Gene_expression (cleavage) of collagen in cleavage
3) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.52 Pain Relevance 0.28
In explants from patients with OA, collagenase-mediated COL2A1 cleavage was frequently downregulated at 10 pg/ml (in the range 1 pg/ml to 10 ng/ml) by PGE2 as well as by 5 ng/ml TGF-?
Negative_regulation (downregulated) of Gene_expression (cleavage) of COL2A1 in cleavage associated with osteoarthritis
4) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206385 Disease Relevance 0.94 Pain Relevance 0.15
The predominant inhibitory effect of PGE2 in OA cartilage explants supports the notion that our previously observed suppression of collagen cleavage by TGF-?
Negative_regulation (suppression) of Gene_expression (cleavage) of collagen in cleavage associated with osteoarthritis
5) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.38 Pain Relevance 0.24
2 in osteoarthritic (OA) cartilage and is itself capable of downregulating collagen cleavage and hypertrophy in human OA articular cartilage.
Negative_regulation (downregulating) of Gene_expression (cleavage) of collagen in articular cartilage associated with hypertrophy and osteoarthritis
6) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206385 Disease Relevance 0.94 Pain Relevance 0.04
However, in most examined cartilages and as shown by the group analyses, significant downregulation of collagen cleavage was observed at 10 pg/ml PGE2 in these four individual patients (Figure 1e) and in a larger cohort of 13 other patients (Figure 1f).
Negative_regulation (downregulation) of Gene_expression (cleavage) of collagen in cartilages
7) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.30 Pain Relevance 0.15
Collagen cleavage was downregulated by exogenous PGE2 at concentrations as low as 0.1 pg/ml (data not shown) and 1 pg/ml in one of four patients (Figure 1b).
Negative_regulation (downregulated) of Gene_expression (cleavage) of Collagen in cleavage
8) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.27 Pain Relevance 0.14
Interestingly, while the SOX9 dependency of COL2A1 expression has been unequivocally shown, it may not actually be a key regulator of COL2A1 promoter activity in human adult articular chondrocytes [82].
Negative_regulation (dependency) of Gene_expression (expression) of COL2A1 in chondrocytes
9) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.12 Pain Relevance 0
also represses the expression of an array of genes associated with the differentiated chondrocyte phenotype, including the type II collagen gene (COL2A1) and aggrecan (AGC) [25], [27], [28].
Negative_regulation (represses) of Gene_expression (expression) of type II collagen gene in chondrocyte
10) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.86 Pain Relevance 0.38
Controversy exists among others about whether COL2A1 expression is increased or suppressed in OA cartilage.
Spec (whether) Negative_regulation (suppressed) of Spec (whether) Gene_expression (expression) of COL2A1 in cartilage associated with osteoarthritis
11) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.23 Pain Relevance 0.55
Aigner and colleagues have suggested that the expression of COL2A1 is suppressed in the upper zones of early OA cartilage, but increased in late-stage OA cartilage relative to normal controls [31], [32].
Negative_regulation (suppressed) of Gene_expression (expression) of COL2A1 in upper associated with osteoarthritis
12) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.17 Pain Relevance 0.52
also represses the expression of an array of genes associated with the differentiated chondrocyte phenotype, including the type II collagen gene (COL2A1) and aggrecan (AGC) [25], [27], [28].
Negative_regulation (represses) of Gene_expression (expression) of COL2A1 in chondrocyte
13) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.87 Pain Relevance 0.39
Indomethacin (0.3-300 nM) or ketoprofen (2-2000 nM) produced a dose-dependent suppression of type II collagen synthesis associated with decreased levels of type II collagen mRNA in the absence of IL-1, while they potentiated the inhibitory effects of IL-1.
Negative_regulation (suppression) of Gene_expression (synthesis) of type II collagen
14) Confidence 0.24 Published 1990 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 2146129 Disease Relevance 0.08 Pain Relevance 0.26
Gruber et al considered that loss of expression of Sox9 in some of the anulus cell population may play a role in disc aging and degeneration, possibly by decreased modulation of the expression and production of Type II collagen of disc cells 36.
Negative_regulation (decreased) of Gene_expression (expression) of Type II collagen associated with aging
15) Confidence 0.20 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0
Gruber et al considered that loss of expression of Sox9 in some of the anulus cell population may play a role in disc aging and degeneration, possibly by decreased modulation of the expression and production of Type II collagen of disc cells 36.
Negative_regulation (decreased) of Gene_expression (production) of Type II collagen associated with aging
16) Confidence 0.20 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0
The results demonstrated that pre-existing marker genes generally showed the expected pattern of expression, that is high expression of ACAN in NP and AC, high expression of type I collagen in AF compared with NP and AC, and high expression of versican (VCAN) in both NP and AF compared with AC.
Negative_regulation (showed) of Gene_expression (expression) of collagen
17) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
In contrast, etodolac (2-2000 nM) maintained expression of type II collagen protein and mRNA.
Negative_regulation (maintained) of Gene_expression (expression) of type II collagen
18) Confidence 0.18 Published 1990 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 2146129 Disease Relevance 0.07 Pain Relevance 0.26
The expression of the genes for collagen type II and aggrecan were decreased by IL-1 treatment of cells derived from the non-degenerate disc, although this decrease was only significant for aggrecan (Fig. 5d,e).


Negative_regulation (decreased) of Gene_expression (expression) of collagen type II
19) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
Studies using explants of human cartilage indicate that catabolic degradation of cartilage matrix, a MMP dependent response, is suppressed by reparagen in concert with increased expression of the cartilage repair factor, IGF-1 [20].
Negative_regulation (suppressed) of Gene_expression (expression) of cartilage repair factor in cartilage
20) Confidence 0.08 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2131759 Disease Relevance 0.10 Pain Relevance 0.17

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