INT20556

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Context Info
Confidence 0.58
First Reported 1990
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.24
Pain Relevance 3.80

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transmembrane transport (Slc9a2)
Anatomy Link Frequency
pons 1
medulla 1
Slc9a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C inhibitor 3 99.96 Very High Very High Very High
Opioid 9 99.38 Very High Very High Very High
Physical dependence 12 99.16 Very High Very High Very High
Potency 1 98.84 Very High Very High Very High
Clonidine 3 98.48 Very High Very High Very High
narcan 9 97.92 Very High Very High Very High
opioid receptor 9 96.00 Very High Very High Very High
antagonist 5 95.36 Very High Very High Very High
withdrawal 6 94.36 High High
sodium channel 4 93.72 High High
Disease Link Frequency Relevance Heat
Drug Dependence 12 99.16 Very High Very High Very High
Heart Rate Under Development 4 97.58 Very High Very High Very High
Rheumatoid Arthritis 3 94.92 High High
Opiate Addiction 3 94.36 High High
Natriuresis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonamiloride compounds known to inhibit the activity of other Na/H exchanger isoforms also inhibited NHE-2 with the following order of potency: clonidine (K0.5 = 42 microM) > harmaline (K0.5 = 330 microM) approximately cimetidine (K0.5 = 330 microM).
Negative_regulation (inhibited) of NHE-2 associated with clonidine and potency
1) Confidence 0.58 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8244989 Disease Relevance 0 Pain Relevance 0.19
The pressor effect and tachycardia caused by LVV-H7 were potentiated by captopril, suggesting that the angiotensin converting enzyme may contribute to the inactivation of LVV-H7 in rats.
Negative_regulation (inactivation) of LVV-H7 associated with heart rate under development
2) Confidence 0.35 Published 1998 Journal Peptides Section Abstract Doc Link 9437744 Disease Relevance 0.17 Pain Relevance 0.21
The pressor activity of DCLHb, in contrast to that elicited by LVV-H7, was not affected by animal pretreatment with LVV-H7 fragments shown to inhibit the pressor effect of LVV-H7.
Negative_regulation (inhibit) of LVV-H7
3) Confidence 0.35 Published 1998 Journal Peptides Section Abstract Doc Link 9437744 Disease Relevance 0.16 Pain Relevance 0.19
Possible involvement of protein kinases in physical dependence on opioids: studies using protein kinase inhibitors, H-7 and H-8.
Negative_regulation (inhibitors) of H-7 associated with physical dependence, narcan and opioid
4) Confidence 0.06 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 8549612 Disease Relevance 0.25 Pain Relevance 1.30
Effects of a cAMP-dependent protein kinase and protein kinase C inhibitor, H-7 (1-(5-isoquinolinesulfonyl)-2-methylpiperazine) and a cAMP- and cGMP-dependent protein kinase inhibitor, H-8 (N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide), on the behavioral signs of naloxone (an opioid receptor antagonist)-precipitated withdrawal syndrome and effects of H-7 on the change of protein kinase C activity in the pons/medulla region induced by morphine (a mu-opioid receptor agonist) or butorphanol (a mu/delta/kappa mixed opioid receptor agonist) were investigated in this study.
Negative_regulation (inhibitor) of H-7 in pons associated with narcan, opioid receptor, morphine, kinase c inhibitor, medulla, kinase c, antagonist, butorphanol, agonist and withdrawal
5) Confidence 0.06 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549612 Disease Relevance 0.17 Pain Relevance 0.92
Ra 1) was near zero within 20 min when extracellular Na+ concentration = 0 and [Ca2+]o = 20 microM and within 5 min or less after preincubation with caffeine, 8-chlorophenylthioadenosine 3',5'-cyclic monophosphate, or at 18 degrees C; 2) was significantly decreased by Cd2+, Ni2+, the isoquinoline H-7, and trifluoperazine but not 100 microM ryanodine; 3) was increased by neomycin; and 4) had an apparent activation energy of 18.5 +/- 4.1 x 10(3) cal/mol between 23 and 42 degrees C.
Negative_regulation (decreased) of isoquinoline H-7 associated with rheumatoid arthritis
6) Confidence 0.04 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2146883 Disease Relevance 0.32 Pain Relevance 0.08
Effects of a cAMP-dependent protein kinase and protein kinase C inhibitor, H-7 (1-(5-isoquinolinesulfonyl)-2-methylpiperazine) and a cAMP- and cGMP-dependent protein kinase inhibitor, H-8 (N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide), on the behavioral signs of naloxone (an opioid receptor antagonist)-precipitated withdrawal syndrome and effects of H-7 on the change of protein kinase C activity in the pons/medulla region induced by morphine (a mu-opioid receptor agonist) or butorphanol (a mu/delta/kappa mixed opioid receptor agonist) were investigated in this study.
Negative_regulation (inhibitor) of H-7 in medulla associated with narcan, opioid receptor, morphine, kinase c inhibitor, medulla, kinase c, antagonist, butorphanol, agonist and withdrawal
7) Confidence 0.02 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549612 Disease Relevance 0.17 Pain Relevance 0.92

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