INT205589

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.02
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COQ2) protein modification process (PPT2) biosynthetic process (COQ2)
lysosome (PPT2)
Anatomy Link Frequency
muscle 2
PPT2 (Homo sapiens)
COQ2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 69.44 Quite High
pruritus 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhabdomyolysis 24 92.88 High High
Dyslipidemia /

Combined Dyslipidemia

4 81.12 Quite High
Muscle Disease 40 75.44 Quite High
Muscle Weakness 4 72.24 Quite High
Pain 16 69.44 Quite High
Myoglobinuria 12 60.32 Quite High
Myositis 8 57.40 Quite High
Arthralgia 12 54.24 Quite High
Myalgia 4 42.88 Quite Low
Fungal Infection 8 31.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under dominant models for each, the COQ2 SNP1 and SNP2 genotypes, and 2-SNP haplotypes were not associated with statin intolerance.
statin Binding (associated) of COQ2
1) Confidence 0.04 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1832194 Disease Relevance 0.09 Pain Relevance 0
But these preliminary pharmacogenetic results are consistent with the idea that statin intolerance which is manifested primarily through muscle symptoms is associated with genomic variation in COQ2 and thus perhaps with the CoQ10 pathway.


statin Binding (associated) of COQ2 in muscle
2) Confidence 0.03 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1832194 Disease Relevance 0.22 Pain Relevance 0.07
These preliminary pharmacogenetic results, if confirmed, are consistent with the idea that statin intolerance which is manifested primarily through muscle symptoms is associated with genomic variation in COQ2 and thus perhaps with the CoQ10 pathway.



statin Binding (associated) of COQ2 in muscle
3) Confidence 0.03 Published 2007 Journal Lipids Health Dis Section Abstract Doc Link PMC1832194 Disease Relevance 0.54 Pain Relevance 0
In this preliminary analysis of a small sample of subjects, we found that genetic variation in COQ2, as defined by two genotypes and a haplotype derived from the two most informative SNPs of this gene, was significantly associated with statin intolerance.
statin Binding (associated) of COQ2
4) Confidence 0.03 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1832194 Disease Relevance 0.09 Pain Relevance 0

General Comments

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