INT205594

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 27
Disease Relevance 12.53
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COQ10A)
Anatomy Link Frequency
muscle 6
mononuclear cells 3
plasma 1
skeletal muscle 1
respiratory 1
COQ10A (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 522 98.76 Very High Very High Very High
Bioavailability 38 89.52 High High
depression 51 83.52 Quite High
headache 14 82.08 Quite High
chronic pain syndrome 18 79.84 Quite High
Pain 22 67.84 Quite High
Peripheral nervous system 1 44.48 Quite Low
pruritus 3 39.40 Quite Low
Central nervous system 13 26.36 Quite Low
Bile 1 7.84 Low Low
Disease Link Frequency Relevance Heat
Sleep Disorders 522 98.76 Very High Very High Very High
Frailty 3 98.72 Very High Very High Very High
Disease 82 98.16 Very High Very High Very High
Ataxia 73 97.80 Very High Very High Very High
Stress 536 96.28 Very High Very High Very High
Parkinson's Disease 103 93.92 High High
Aging 12 93.84 High High
Cerebellar Ataxia 37 93.56 High High
Syndrome 18 89.68 High High
Diabetes Mellitus 18 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is well established that CoQ10 is synthesized de novo in all tissues, and hence, under normal circumstances, most tissues are not dependent on an exogenous supply of CoQ10.
Gene_expression (synthesized) of CoQ10
1) Confidence 0.67 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.17 Pain Relevance 0
In the current study, it is evident that intramuscular CoQ10 levels increased following each testing session (T2 Pre to Post and T3 Pre to Post); while the placebo group showed an overall decrease in intramuscular CoQ10 levels (Figure 4).
Gene_expression (levels) of CoQ10
2) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.17 Pain Relevance 0.03
In the present study, the pre-supplementation concentration of muscle CoQ10 (14.96 ± 10.3 ?
Gene_expression (concentration) of CoQ10 in muscle
3) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0 Pain Relevance 0
Formulations that could maximize CoQ10 absorption would not only improve its uptake into the plasma, but potentially improve its absorption into the skeletal muscle.
Gene_expression (absorption) of CoQ10 in skeletal muscle
4) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0 Pain Relevance 0.04
SOD levels after the isokinetic muscle endurance test were significantly lower in the CoQ10 compared to CON group (p < 0.05).
Gene_expression (lower) of CoQ10 in muscle
5) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.19 Pain Relevance 0
Though no significant changes were observed following chronic supplementation, it is evident from Figure 4 that muscle CoQ10 concentration was generally higher after baseline in the CoQ10-supplemented group compared to placebo group.
Gene_expression (concentration) of CoQ10 in muscle
6) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0 Pain Relevance 0
In fact, muscle CoQ10 levels declined in the placebo group over the 2-week period.
Gene_expression (levels) of CoQ10 in muscle
7) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0 Pain Relevance 0
A trend towards a significant group × time interaction (p = 0.098) was observed on day 0 (T2), indicating higher muscle CoQ10 levels (mcg/mg) following an acute ingestion of CoQ10.
Gene_expression (levels) of CoQ10 in muscle
8) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0 Pain Relevance 0
In the current study, it is evident that intramuscular CoQ10 levels increased following each testing session (T2 Pre to Post and T3 Pre to Post); while the placebo group showed an overall decrease in intramuscular CoQ10 levels (Figure 4).
Gene_expression (levels) of CoQ10
9) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.19 Pain Relevance 0.03
However, whether a maximal limit and/or down regulation in the transport of CoQ10 into the muscle occurs following chronic CoQ10 supplementation is highly speculative and requires further investigation
Gene_expression (supplementation) of CoQ10 in muscle
10) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.15 Pain Relevance 0
A trend towards a significant group × gender (p = 0.09) and training status × gender (p = 0.06) interaction were observed, indicating higher levels of CoQ10 in both trained and male subjects respectively.
Gene_expression (levels) of CoQ10
11) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0 Pain Relevance 0
Additionally, serum MDA levels were significantly higher in the CoQ10 compared to placebo group (p < 0.05) following the Wingate anaerobic capacity test and aerobic capacity test.
Gene_expression (higher) of CoQ10
12) Confidence 0.58 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 1.04 Pain Relevance 0
A negative correlation was seen between the expression of autophagic genes and CoQ10 levels (r = -0.80, P < 0.01 for BECLIN 1, and r = -0.76, P < 0.001 for MAP-LC3) (Figure 5c).
Gene_expression (expression) of CoQ10
13) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 0.37 Pain Relevance 0.18
Previously, we detected decreased coenzyme Q10 (CoQ10) levels and increased reactive oxygen species (ROS) production in blood mononuclear cells of FM patients, providing direct evidence of increased oxidative stress at the cellular level [5].
Gene_expression (production) of CoQ10 in mononuclear cells associated with stress and fibrositis
14) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 0.92 Pain Relevance 0.37
Measurement of CoQ10 levels
Gene_expression (levels) of CoQ10
15) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 0.36 Pain Relevance 0.13
CoQ10deficiency has been associated with a variety of human disorders, some of them caused by a direct defect of CoQ10 biosynthesis genes or as a secondary consequence of other diseases [18,19].
Gene_expression (biosynthesis) of CoQ10 associated with disease
16) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 0.31 Pain Relevance 0.10
Statistical analyses included Pearson's correlations between CoQ10 levels and autophagic gene expression levels.
Gene_expression (expression) of CoQ10
17) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 0.56 Pain Relevance 0.27
Only lipophilic antioxidants, CoQ10 and ?
Gene_expression (antioxidants) of CoQ10
18) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 0.99 Pain Relevance 0.40
We found reduced levels of coenzyme Q10, decreased mitochondrial membrane potential, increased levels of mitochondrial superoxide in blood mononuclear cells, and increased levels of lipid peroxidation in both blood mononuclear cells and plasma from fibromyalgia patients.
Gene_expression (levels) of coenzyme Q10 in mononuclear cells associated with fibrositis
19) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875645 Disease Relevance 1.11 Pain Relevance 0.32
Previously, we detected decreased coenzyme Q10 (CoQ10) levels and increased reactive oxygen species (ROS) production in blood mononuclear cells of FM patients, providing direct evidence of increased oxidative stress at the cellular level [5].
Gene_expression (production) of coenzyme Q10 in mononuclear cells associated with stress and fibrositis
20) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 0.93 Pain Relevance 0.37

General Comments

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