INT2056

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 175
Total Number 179
Disease Relevance 33.43
Pain Relevance 63.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
pituitary 21
neurons 17
MBH 12
follicle 10
plasma 7
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 511 100.00 Very High Very High Very High
narcan 302 100.00 Very High Very High Very High
agonist 279 100.00 Very High Very High Very High
Morphine 257 100.00 Very High Very High Very High
Opioid 117 100.00 Very High Very High Very High
Neuropeptide 67 100.00 Very High Very High Very High
Somatostatin 58 100.00 Very High Very High Very High
Enkephalin 48 100.00 Very High Very High Very High
depression 35 100.00 Very High Very High Very High
Immobilon 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 504 100.00 Very High Very High Very High
Depression 38 100.00 Very High Very High Very High
Galactorrhea 88 99.84 Very High Very High Very High
Uremia 24 99.84 Very High Very High Very High
Nerve Degeneration 42 99.66 Very High Very High Very High
Aging 19 99.62 Very High Very High Very High
Congenital Anomalies 15 99.54 Very High Very High Very High
Reprotox - General 3 27 99.24 Very High Very High Very High
Reprotox - General 1 89 99.12 Very High Very High Very High
Urological Neuroanatomy 28 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum luteinizing hormone was also suppressed by EtOH; however, naltrexone did not abrogate this fall.
Negative_regulation (suppressed) of Serum luteinizing hormone
1) Confidence 0.59 Published 1999 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 10029204 Disease Relevance 0 Pain Relevance 0.18
Serum luteinizing hormone and testosterone levels decreased, but serum follicle-stimulating hormone levels increased.
Negative_regulation (decreased) of Serum luteinizing hormone in follicle
2) Confidence 0.59 Published 1977 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 325255 Disease Relevance 0.18 Pain Relevance 0.42
However, naloxone acts as an antagonist on the Diallyl-G-induced inhibition of GnRH release. 4.
Negative_regulation (inhibition) of GnRH associated with antagonist and narcan
3) Confidence 0.59 Published 1995 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8565043 Disease Relevance 0 Pain Relevance 0.93
Also, there was a reduction in pituitary GnRH receptors which was consistent with hypothalamic GnRH deficiency.
Negative_regulation (deficiency) of GnRH in pituitary
4) Confidence 0.59 Published 1985 Journal Endocrinology Section Abstract Doc Link 3886368 Disease Relevance 0.07 Pain Relevance 0.23
The LHRH content of the tolerant rats was decreased during withdrawal of morphine for 48 hr when the lowered serum testosterone and LH levels had returned to within the control levels.
Negative_regulation (decreased) of LHRH associated with withdrawal and morphine
5) Confidence 0.58 Published 1978 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 356791 Disease Relevance 0 Pain Relevance 0.68
A 87 and 44% depletion of LHRH and SRIF content respectively and a 50% decrease in the number of specific opiate binding sites was observed in the deafferented MBH.
Negative_regulation (depletion) of LHRH in MBH associated with opiate
6) Confidence 0.58 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6124436 Disease Relevance 0 Pain Relevance 0.40
It has been shown in developing male rats that morphine maximally depresses serum luteinizing hormone (LH) levels as early as postnatal day 15.
Negative_regulation (depresses) of serum luteinizing hormone associated with morphine
7) Confidence 0.58 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2839658 Disease Relevance 0 Pain Relevance 0.47
LHRH level was decreased by 1000 microM of morphine regardless of the duration of exposure or differentiation status of the SK-N-SH cells and was not reversed by naloxone.
Negative_regulation (decreased) of LHRH in SK-N-SH associated with narcan and morphine
8) Confidence 0.58 Published 2003 Journal Neuropeptides Section Abstract Doc Link 14607103 Disease Relevance 0.09 Pain Relevance 0.87
LHRH level was decreased by 1000 microM of morphine regardless of the duration of exposure or differentiation status of the SK-N-SH cells and was not reversed by naloxone.
Neg (not) Negative_regulation (reversed) of LHRH in SK-N-SH associated with narcan and morphine
9) Confidence 0.58 Published 2003 Journal Neuropeptides Section Abstract Doc Link 14607103 Disease Relevance 0.09 Pain Relevance 0.93
The results of this study imply that (1) delta opioid receptors may mediate the inhibitory effect of lower concentrations of morphine on LHRH levels in SK-N-SH cells, and (2) inhibition of LHRH level by high concentrations of morphine may involve systems other than opioid receptors.
Negative_regulation (inhibition) of LHRH in SK-N-SH associated with opioid receptor, delta opioid receptors and morphine
10) Confidence 0.58 Published 2003 Journal Neuropeptides Section Abstract Doc Link 14607103 Disease Relevance 0.07 Pain Relevance 0.92
Selective antagonism of micro opioid receptors, but not delta opioid receptors, allowed lower concentrations (1-100 microM) of morphine to inhibit LHRH.
Negative_regulation (inhibit) of LHRH associated with delta opioid receptors, opioid receptor and morphine
11) Confidence 0.58 Published 2003 Journal Neuropeptides Section Abstract Doc Link 14607103 Disease Relevance 0.08 Pain Relevance 0.93
Delta opioid receptors are involved in morphine-induced inhibition of luteinizing hormone releasing hormone in SK-N-SH cells.
Negative_regulation (inhibition) of luteinizing hormone in SK-N-SH associated with delta opioid receptors and morphine
12) Confidence 0.58 Published 2003 Journal Neuropeptides Section Title Doc Link 14607103 Disease Relevance 0.09 Pain Relevance 0.91
The results show that, although exogenous GABAA receptor agonist is capable of inhibiting the activity of LHRH pulse generator, the reduction in the endogenous GABAA receptor activity does not cause a significant effect, suggesting a minor role of inhibitory GABA neurons in the control of pulsatile release of LHRH.
Negative_regulation (inhibiting) of LHRH pulse generator in neurons associated with gaba and agonist
13) Confidence 0.58 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8396216 Disease Relevance 0 Pain Relevance 0.43
In chronically stressed rats there was a decrease in hypothalamic luteinizing hormone-releasing hormone (LHRH) content and the response on plasma gonadotropins to LHRH administration was enhanced.
Negative_regulation (decrease) of LHRH in plasma
14) Confidence 0.58 Published 1991 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 1958548 Disease Relevance 0.42 Pain Relevance 0.05
Suppression of pulsatile LH secretion, pituitary GnRH receptor content and pituitary responsiveness to GnRH by hyperprolactinemia in the male rat.
Negative_regulation (responsiveness) of GnRH in pituitary associated with galactorrhea and narcan
15) Confidence 0.58 Published 1987 Journal Neuroendocrinology Section Title Doc Link 2823160 Disease Relevance 0.45 Pain Relevance 0.26
High postovariectomy LH levels are not due to decreased opioid inhibition of GnRH.
Negative_regulation (inhibition) of GnRH associated with narcan and opioid
16) Confidence 0.58 Published 1991 Journal Brain Res. Bull. Section Title Doc Link 1651151 Disease Relevance 0 Pain Relevance 0.48
Corticotrophin-releasing hormone (CRH) neurones in the paraventricular nucleus that project axons to the median eminence probably do not directly inhibit GnRH, but either afferent or parallel central pathways are involved.
Negative_regulation (inhibit) of GnRH in median eminence
17) Confidence 0.57 Published 2003 Journal Reprod. Suppl. Section Abstract Doc Link 14635941 Disease Relevance 0.29 Pain Relevance 0.08
The decrease of hypothalamic LHRH in castrated rats was completely blocked by testosterone propionate or morphine sulfate administration.
Negative_regulation (decrease) of LHRH associated with morphine
18) Confidence 0.57 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 7041002 Disease Relevance 0 Pain Relevance 0.48
Naloxone (500 micrograms), however, induced a twofold increase in LH levels within 15 min suggesting that an enhanced opiate rather than dopaminergic activity may be responsible for the suppression of GnRH and hence gonadotrophin secretion during suckling.
Negative_regulation (suppression) of GnRH associated with narcan and opiate
19) Confidence 0.54 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6420492 Disease Relevance 0 Pain Relevance 0.41
Castration caused a 57% depletion of MBH LHRH in N rats; in castrated H rats the MBH LHRH content was also reduced by 40%, a significantly lesser extent.
Negative_regulation (reduced) of MBH LHRH in MBH
20) Confidence 0.51 Published 1987 Journal Endocrinology Section Abstract Doc Link 3297642 Disease Relevance 0.38 Pain Relevance 0.09

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