INT205607

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.34
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
cleft 1
Fgf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 16 88.28 High High
anesthesia 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
vagus nerve 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Disorder 8 99.64 Very High Very High Very High
Cleft Palate 16 99.24 Very High Very High Very High
Cancer 88 98.00 Very High Very High Very High
Inborn Genetic Diseases 3 97.08 Very High Very High Very High
Targeted Disruption 91 94.72 High High
Colon Cancer 1 93.32 High High
Obesity 17 91.92 High High
Apoptosis 42 90.40 High High
Cicatrix 1 76.40 Quite High
Death 4 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, serum hormone-like Fgf levels are significantly affected by some metabolic diseases.
Regulation (affected) of Fgf associated with metabolic disorder
1) Confidence 0.24 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.63 Pain Relevance 0.04
Mice carrying a large deletion of chromosome 14 (Pub36-/-), a region that contains the Spry2 gene exhibit cleft palate, excessive cell proliferation and up regulation of FGF target genes including Msx1, Etv5 and Barx1 [19].
Regulation (regulation) of FGF in cleft associated with cleft palate
2) Confidence 0.19 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.43 Pain Relevance 0
Spry1 and Spry2 have overlapping domains of expression during development and current data suggest that they may be functionally redundant in regulating FGF signaling [13].
Regulation (regulating) of FGF
3) Confidence 0.14 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.31 Pain Relevance 0
The anti-tumor activity of SU6668 has been attributed to its antiangiogenic potential arising from its inhibitory effect on the receptor-tyrosine kinase activity of VEGF, FGF, and PDGF.
Regulation (effect) of FGF associated with cancer
4) Confidence 0.08 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1832206 Disease Relevance 1.97 Pain Relevance 0

General Comments

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