INT205614

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kdr) kinase activity (Kdr) cytoplasm (Kdr)
Anatomy Link Frequency
fibroblast 1
Gm6668 (Mus musculus)
Kdr (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chondrosarcoma 46 97.88 Very High Very High Very High
Cancer 166 97.20 Very High Very High Very High
Malignant Neoplastic Disease 12 90.56 High High
Bone Cancer 12 89.12 High High
Solid Tumor 8 87.04 High High
Severe Combined Immunodeficiency 8 68.16 Quite High
Lung Cancer 4 57.76 Quite High
Body Weight 12 46.88 Quite Low
Metastasis 2 34.00 Quite Low
Apoptosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is strong experimental evidence that SU6668, an inhibitor of the angiogenic tyrosine kinases Flk-1/KDR, PDGFRbeta and FGFR1 can induce growth inhibition of various primary tumors.
SU6668 Negative_regulation (inhibitor) of KDR associated with cancer
1) Confidence 0.01 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1832206 Disease Relevance 0.94 Pain Relevance 0
SU6668 is a small-molecule inhibitor of the receptor tyrosine kinases Flk-1/KDR (vascular endothelial growth factor receptor 2, VEGR2), PDGFRbeta (platelet-derived growth factor receptor beta) and FGFR1 (fibroblast growth factor receptor 1), which play an important role in angiogenesis, as they transduce the signals of the key angiogenic growth factors VEGF, PDGF and bFGF.
SU6668 Negative_regulation (inhibitor) of KDR in fibroblast
2) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1832206 Disease Relevance 0.55 Pain Relevance 0

General Comments

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